Intro -- 1 Introduction and aim of the thesis -- 2 Theoretical background -- 2.1 Lentzea aerocolonigenes and rebeccamycin -- 2.2 Morphology and productivity of filamentous microorganisms -- 2.3 Bubble-free aeration in bioreactors -- 3 Material and methods -- 3.1 Strain and cultivation medium -- 3.2 Particles -- 3.3 Cultivation methods -- 3.4 Analytical methods -- 3.5 Investigation of the pellet structure -- 4 Results and discussion -- 4.1 Microparticle enhanced cultivation -- 4.2 Macroparticle enhanced cultivation -- 4.3 Membrane aerated stirred bioreactor cultivations
4.4 Particle-based rebeccamycin recovery with adsorbent resins -- 5 Conclusions and future prospects -- 6 List of abbreviations and symbols -- 7 References
