| Description |
1 online resource (ix, 285 pages) : illustrations |
| Contents |
Introduction to fragment-based drug discovery / Mike Cherry and Tim Mitchell -- Designing a fragment process to fit your needs / Edward R. Zartler and Michael J. Shapiro -- Assembling a fragment library / Mark Brewer [and others] -- Practical aspects of using NMR in fragment-based screening / Johan Schultz -- Application of protein-ligand NOE matching to the rapid evaluation of fragment binding poses / William J. Metzler [and others] -- Target-immobilized NMR screening : validation and extension to membrane proteins / Virginie Früh, Robert J. Heetebrij, and Gregg Siegal -- In situ fragment-based medicinal chemistry : screening by mass spectrometry / Sally-Ann Poulsen and Gary H. Kruppa -- Computational approaches to fragment and substructure discovery and evaluation / Eelke van der Horst and Adriaan P. IJzerman -- Virtual fragment scanning : current trends, applications and web-based tools / Bradley Feuston [and others] -- Capture methods for fragment-based lead discovery / Stig K. Hansen and Daniel A. Erlanson -- Identification of high affinity [beta]-secretase inhibitors using fragment-based lead generation / Jeffrey S. Albert and Philip D. Edwards |
| Summary |
Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole source of drug discovery. ℗¡ Fragment-Based Drug Discovery: A Practical Approach is a guide to the techniques and practice of using fragments in drug screening. The emphasis is on practical guidance, with procedures, case studies, practical tips, and co |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Drug development.
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Drugs -- Design.
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Ligands (Biochemistry)
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Drug Design.
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Ligands.
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Magnetic Resonance Spectroscopy -- methods.
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| Form |
Electronic book
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| Author |
Shapiro, Michael (Michael J.)
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Zartler, Edward.
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Wiley InterScience (Online service)
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| ISBN |
0470721553 |
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0470721561 (electronic bk.) |
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1282342754 |
|
9780470721551 |
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9780470721568 (electronic bk.) |
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9781282342750 |
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(cloth) |
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(cloth) |
|
