| Description |
1 online resource (947 pages) : illustrations (some color) |
| Series |
Elsevier science & technology books |
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Elsevier science & technology books
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| Contents |
Front Cover; The Parathyroids: Basic and clinical concepts; Copyright; Contents; Contributors; Preface to the Third Edition; Preface to the Second Edition; Preface to the First Edition; Introduction -- A History of the Parathyroid Glands and their Secretory Product, Parathyroid Hormone; PREHISTORIC DEVELOPMENT; DISCOVERY OF THE PARATHYROID GLANDS; DISCOVERY OF THE PARATHYROIDS' ACTIVE PRINCIPLE; THE SEARCH FOR MECHANISMS OF PTH ACTION; MODERN APPROACHES TO PTH STRUCTURE AND FUNCTION; PRIMARY HYPERPARATHYROIDISM-A NEW DISEASE |
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HUMORAL HYPERCALCEMIA OF MALIGNANCY AND THE DISCOVERY OF PARATHYROID HORMONE-RELATED PROTEIN (PTHRP)REDISCOVERY OF THE ANABOLIC EFFECT OF PTH; PTH: A TREATMENT FOR OSTEOPOROSIS; CONCLUSION; References; Section I -- Molecular, Cellular, and Physiologic Aspects of The Parathyroids; Chapter 1 -- Parathyroids: Morphology and Pathology; Morphology and Pathology; INTRODUCTION; EMBRYOLOGY; ANATOMY AND HISTOLOGY; HYPERPARATHYROIDISM; FAMILIAL HYPERPARATHYROIDISM; UNUSUAL LESIONS OF THE PARATHYROID; INTRAOPERATIVE ASSESSMENT OF PARATHYROID-OLD AND NEW; SPECIAL STUDIES AND THE PARATHYROID |
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HUMORAL HYPERCALCEMIA OF MALIGNANCYHYPOPARATHYROIDISM; References; Chapter 2 -- Parathyroid Hormone Gene: Structure, Evolution, and Regulation; Structure, Evolution, and Regulation; INTRODUCTION; PREPROPTH; GENE STRUCTURE; EVOLUTION; REGULATION; References; Chapter 3 -- Parathyroid Hormone-related Protein: Gene Structure, Biosynthesis, Metabolism and Regulation; Gene Structure, Biosynthesis, Metabolism and Regulation; INTRODUCTION; ISOLATION AND CLONING OF PTHRP; GENE STRUCTURE; TRANSCRIPTIONAL REGULATION AND MRNA SPLICING; PROTEIN STRUCTURE AND POSTTRANSLATIONAL PROCESSING |
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NUCLEAR IMPORT AND INTRACRINE FUNCTION OF PTHRPTISSUE DISTRIBUTION AND PARACRINE FUNCTION; CONCLUSION; References; Chapter 4 -- Interactions of PTH with Receptors and Signaling; INTRODUCTION; PARATHYROID HORMONE-LIGAND DETERMINANTS OF BIOLOGICAL ACTIVITY; THE PTHR1 CLONING, GENE CHARACTERIZATION, AND EVOLUTION; STRUCTURAL FEATURES OF THE PTHR1 AND MODE OF LIGAND BINDING; LIGAND INTERACTIONS TO THE RECEPTOR'S N-TERMINAL EXTRACELLULAR DOMAIN (ECD); THE PTHR1 TRANSMEMBRANE DOMAIN (TMD) REGION, STRUCTURE, AND MODE OF ACTION; MECHANISMS OF SIGNALING TRANSDUCTION AND SIGNAL REGULATION |
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MECHANISM OF CONFORMATIONAL CHANGE AND PROLONGED SIGNALING AT THE PTHR1SMALL MOLECULE LIGANDS FOR THE PTHR; References; Chapter 5 -- Interactions of PTHrP with Receptors and Signaling; INTRODUCTION; STRUCTURES OF THE PTHRP GENE, MRNA, AND PEPTIDES; N-TERMINAL PTHRP AND RECEPTORS; MID-MOLECULAR PTHRP AND RECEPTORS; NUCLEAR/NUCLEOLAR PTHRP AND ITS RECEPTORS; C-TERMINAL PTHRP AND ITS RECEPTORS; CONCLUSIONS; References; Chapter 6 -- Control of Parathyroid Hormone Secretion by its Key Physiological Regulators; INTRODUCTION; IMPORTANCE OF PTH IN MAINTAINING MINERAL ION HOMEOSTASIS IN VIVO |
| Summary |
The third edition of The Parathyroids, led by a new stellar editorial team, has been thoroughly updated to reflect the considerable advances in just about every aspect of PTH biology over the past decade. It continues to be the authoritative reference that spans the basic science of parathyroid hormone treatment to major clinical disorders in a superb, single compendium. This translational resource is invaluable to graduate students, fellows, researchers, and research clinicians in the fields of endocrinology, bone biology, osteology, and rheumatology |
| Bibliography |
Includes bibliographical references at the end of each chapters and index |
| Notes |
Print version record |
| Subject |
Parathyroid glands -- Diseases.
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Parathyroid glands -- Pathophysiology
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Parathyroid glands -- Physiology
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Parathyroid Diseases -- physiopathology
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Parathyroid Diseases
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Parathyroid Diseases -- therapy
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Parathyroid Glands -- physiology
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Parathyroid Hormone -- physiology
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Parathyroid glands -- Diseases
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| Form |
Electronic book
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| Author |
Bilezikian, John P., editor.
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Marcus, Robert (Physician), editor
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Levine, Michael A., 1950- editor.
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Marcocci, Claudio, editor
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Silverberg, Shonni J., editor
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Potts, John T., 1932- editor.
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| ISBN |
9780123977908 |
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0123977908 |
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