| Description |
1 online resource (125 pages) : illustrations (some color) |
| Series |
Molecular biology intelligence unit |
|
Molecular biology intelligence unit (Unnumbered)
|
| Contents |
Allosteric ribozymes as molecular switches and sensors / Garrett A. Soukup -- Ribozymes and deoxyribozymes switched by oligonucleotides / Dipankar Sen and Edward K.Y. Leung -- Ribozymes switched by proteins / Tan Inoue and Yoshiya Ikawa -- Fluorescence-signaling nucleic acid-based sensors / Razvan Nutiu, Lieven P. Billen, and Yingfu Li -- Protein-induced RNA switches in nature / Oliver Mayer [and others] -- Riboswitches as genetic control elements / Ali Nahvi and Ronald R. Breaker -- Switchable RNA motifs as drug targets / Eric Westhof, Boris François, and Quentin Vicens |
| Summary |
In this book, seven chapters describe studies aimed at understanding and exploiting the key features of such molecular RNA and DNA devices. In the first section of the book, four chapters are devoted to artificial nucleic acid switches and sensors. These chapters introduce the concept of allosteric ribozymes as molecular switches and sensors; describe nucleic acid enzymes that are switched by oligonucleotides and other nucleic acid enzymes that are switched by proteins; and illustrate how switching elements can be integrated ration-ally into fluorescently signaling molecular sensors made out of nucleic acids. In the second section of the book, three chapters show that nature has been as crafty a molecular-scale engineer as any modern scientist via evolution of natural nucleic acid switches and sensors. RNAs have been found whose activities are modulated either by proteins or by small-molecule metabolites, and both kinds of system are described. Finally, the notion of exploiting naturally occurring RNA switches for drug development is discussed |
| Analysis |
microbiologie |
|
microbiology |
|
biomedische wetenschappen |
|
biomedicine |
|
humane genetica |
|
human genetics |
|
Medicine (General) |
|
Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Catalytic RNA.
|
|
Biosensors.
|
|
RNA -- Biotechnology
|
|
Nucleic acids.
|
|
Nucleic Acids
|
|
Biosensing Techniques
|
|
Genes, Switch
|
|
RNA, Catalytic -- metabolism
|
|
Biomédecine.
|
|
Sciences de la vie.
|
|
Nucleic acids
|
|
Biosensors
|
|
Catalytic RNA
|
|
RNA -- Biotechnology
|
| Form |
Electronic book
|
| Author |
Silverman, Scott K
|
| LC no. |
2006023015 |
| ISBN |
9780387472577 |
|
0387472576 |
|
