| Description |
1 online resource (214 p.) |
| Contents |
Cover -- Half Title -- Title -- Copyright -- Contents -- Foreword -- Preface -- Acknowledgments -- About the Editors -- List of Contributors -- Chapter 1 A Species within a Species -- References -- Chapter 2 Therapy as a Driver of Evolutionary Selection -- 2.1 Cancer: The Origin Event -- 2.2 Early Tumor Growth -- 2.3 Small Invasive Populations -- 2.3.1 Prevention of Primary Tumors -- 2.3.2 Prevention of Metastatic Tumors -- 2.4 Evolution-Based Treatment of Disseminated Cancers -- 2.4.1 Response to Treatment and the Cost of Resistance -- 2.4.2 Dynamic of Anthropocene Extinctions |
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2.4.3 Applying Game Theory to Oncologic Treatment -- 2.4.4 Adaptive and Extinction (First Strike, Second Strike) Therapies -- 2.5 Conclusion -- References -- Chapter 3 The Genetic Hitchhiker's Guide to Tumor Evolution -- 3.1 Introduction -- 3.1.1 A Tumor's Eye View of Evolution -- 3.2 Mostly Harmless: The Distribution of Fitness Effects of Somatic Mutations -- 3.2.1 Background: Mutations Vary in Their Fitness Effects -- 3.2.2 Mechanisms of Selection: The Hallmarks of Cancer -- 3.2.3 Intrinsic Selection Pressures -- 3.2.4 Extrinsic Selection Pressures |
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3.2.5 Selection Pressures in Novel Environments -- 3.2.6 Evidence of Somatic Mutations That Have Different Fitness Effects -- 3.2.7 Chance in Tumor Evolution -- 3.3 Linkage and Natural Selection in Tumors -- 3.3.1 Genetic Hitchhiking, Background Selection, and Muller's Ratchet -- 3.3.2 Driver and Passenger Mutations -- 3.3.3 Clonal Evolution of Tumors -- 3.4 Tumor Evolution in Changing Environments -- 3.4.1 Characteristics of the Tumor Microenvironment -- 3.4.2 Phenotypic Plasticity in Cancer Evolution -- 3.5 Metastasis -- 3.5.1 Founder Effects and Metastasis -- 3.5.2 Mechanisms of Metastasis |
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3.5.3 Plasticity and Metastasis -- 3.5.4 Cell Fusions and Metastasis -- 3.5.5 Always Metastasizing-Hematologic Cancers -- 3.6 Don't Panic! -- 3.6.1 So Long and Thanks for All the Fish -- References -- Chapter 4 Multicellularity, Phenotypic Heterogeneity, and Cancer -- 4.1 Introduction: Cancer and Multicellularity -- 4.2 Benefits and Disadvantages of Multicellularity: Environmental Variation -- 4.3 Noise, Survival, and Evolution -- 4.4 Synthetic Biological Control of Heterogeneity and Multicellularity -- 4.5 Conclusions -- References |
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Chapter 5 Feedback Loops in Gene Regulatory Networks and Cell-Cell Communication Networks: Drivers of Cancer Cell Plasticity -- 5.1 Introduction -- 5.2 Epithelial-Mesenchymal Plasticity (EMP) -- 5.3 Cancer Stem Cell (CSC) Plasticity -- 5.4 Metabolic Reprogramming/Plasticity -- 5.5 Conclusion -- References -- Chapter 6 Polygenic Evolution of Germline Variants in Cancer -- 6.1 Introduction -- 6.2 Selection Acting on Complex Traits -- 6.3 Sets of Cancer-Associated Alleles -- 6.3.1 Genomic Datasets Analyzed Here -- 6.3.2 Effect Sizes of Germline Variants That Are Associated with Cancer |
| Summary |
Cancer cells exist in an ever-changing ""ecology"" and are subject to evolutionary pressures just like any species in nature. The book is resource for understanding cancer as a disease of multicellularity grounded in evolutionary principles. By using this knowledge, researchers are starting to exploit these behaviors for treatment paradigms |
| Notes |
Description based upon print version of record |
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6.3.3 Allele Frequencies of Germline Variants That Are Associated with Cancer |
| Form |
Electronic book
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| Author |
Johnson, Norman A
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| ISBN |
9781040027684 |
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1040027687 |
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