Description |
1 online resource (xv, 396 pages) |
Contents |
Machine generated contents note: 1. Modeling in Biomedical Research and Health Care / Erik Mosekilde -- 2. Concepts in Mechanism Based Modeling / Erik Mosekilde -- 3. Approach to Model Building / Erik Mosekilde -- 4. Emergence of Oscillatory Dynamics / Erik Mosekilde -- 5. Conductance-Based Models for the Evaluation of Brain Functions, Disorders, and Drug Effects / Hans A. Braun -- 6. Functional Modeling of Neural-Glial Interaction / Olga V. Sosnovtseva -- 7. Activity-Related Structural Changes in the Myelinated Nerve Fiber / Georgy V. Maksimov -- 8. Closed-Loop Control of Brain Rhythms / Julien Modolo -- 9. Modeling Ca2+ Microdomains / Niels-Henrik Holstein-Rathlou -- 10. Synchronization of Cellular Contractions in the Arteriolar Wall / Niels-Henrik Holstein-Rathlou -- 11. Microvascular Plasticity / Niels-Henrik Holstein-Rathlou -- 12. Bifurcations and Multistability in Periodically Stimulated Cardiac Cells / Elena Surovyatkina -- 13. Synchronization: A Case in Biological Studies / Alexander G. Balanov -- 14. Multilevel-Modeling, Core Predictions, and the Concept of Final Conclusions / Gunnar Cedersund -- 15. Absorption Kinetics of Insulin Mixtures after Subcutaneous Administration / Morten Colding-Jørgensen -- 16. Physiologically-Based Pharmacokinetics / Amin Rostami-Hodjegan |
Summary |
Biosimulation is an approach to biomedical research and the treatment of patients in which computer modeling goes hand in hand with experimental and clinical work. Constructed models are used to interpret experimental results and to accumulate information from experiment to experiment. The book explains the concepts used in the modeling of biological phenomena and goes on to present a series of well-documented models of the regulation of various cellular and physiological processes, emphasizing particularly the role of self-sustained biological activity. The way how the use of computer models allows optimization of the treatment of various diseases for individual patients is discussed and models of interacting nerve cells that can be used to design new treatments for patients with Parkinson's disease are explained. Furthermore this volume provides a discussion of the use of models in the pharmaceutical industry, and presents the view of the regulatory agencies on the topic |
Analysis |
Medicine |
|
Pharmaceutical technology |
|
Pharmacy |
|
Bioinformatics |
|
Statistics |
|
Biomedicine |
|
Pharmaceutical Sciences/Technology |
|
Medicine/Public Health, general |
|
Biophysics and Biological Physics |
|
Computational Biology/Bioinformatics |
|
Statistics for Life Sciences, Medicine, Health Sciences |
|
levenswetenschappen |
|
life sciences |
|
geneeskunde |
|
toegepaste statistiek |
|
applied statistics |
|
volksgezondheid |
|
public health |
|
computational science |
|
biomedische wetenschappen |
|
farmacologie |
|
pharmacology |
|
farmacie |
|
biofysica |
|
biophysics |
|
Medicine (General) |
|
Geneeskunde (algemeen) |
Bibliography |
Includes bibliographical references and index |
Subject |
Medicine -- Research -- Simulation methods
|
|
Biology -- Research -- Simulation methods
|
|
Drug development -- Simulation methods
|
|
Systems biology.
|
|
Drugs -- Design.
|
|
Chemotherapy.
|
|
Biological models.
|
|
Biomedical Research
|
|
Computer Simulation
|
|
Drug Design
|
|
Drug Therapy
|
|
Models, Biological
|
|
Systems Biology
|
|
simulation.
|
|
HEALTH & FITNESS -- Holism.
|
|
HEALTH & FITNESS -- Reference.
|
|
MEDICAL -- Alternative Medicine.
|
|
MEDICAL -- Atlases.
|
|
MEDICAL -- Essays.
|
|
MEDICAL -- Family & General Practice.
|
|
MEDICAL -- Holistic Medicine.
|
|
MEDICAL -- Osteopathy.
|
|
Drugs -- Design
|
|
Chemotherapy
|
|
Biological models
|
|
Systems biology
|
Form |
Electronic book
|
Author |
Mosekilde, Erik
|
|
Sosnovtseva, Olga
|
|
Rostami-Hodjegan, Amin
|
ISBN |
9783709104187 |
|
3709104181 |
|