| Description |
1 online resource |
| Contents |
Front Cover; The Protective Arm of the Renin-Angiotensin System: Functional Aspects and Therapeutic Implications; Copyright; Contents; Contributors; Chapter 1: The Angiotensin AT 2 Receptor: From Enigma to Therapeutic Target ; Introduction; References; Chapter 2: The AT 2 Receptor: Historical Perspective ; Background to the Early Involvement of Ciba-Geigy in the Angiotensin Field; Two Ang II Receptor Subtypes; Angiotensin II Receptor Nomenclature; Early Research on the Role of the AT 2 Receptor; Conclusion; References; Chapter 3: Animal Models with a Genetic Alteration of AT 2 Expression |
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IntroductionBlood Pressure; Cardiac Disease; Vascular Disease; Renal Disease; Neural Disease; Conclusion; References; Chapter 4: AT 2 Receptor Signaling: Solved and Unsolved; Introduction; AT 2 R Dimerization; Proliferation and Differentiation; Apoptosis; Inflammation; Fibrosis; Solved and Unsolved Issues; References; Chapter 5: AT 1 R -- AT 2 R Cross Talk; Cross Regulation of Angiotensin II Type 1 Receptor and the Angiotensin II Type 2 Receptor; Functional Significance of the AT 1 R -- AT 2 R Cross Talk; Conclusion; References; Chapter 6: The Angiotensin AT 2 Receptor in Myocardial Infarction |
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IntroductionAT 2 Receptor Expression in the Heart; Acute-Phase Postmyocardial Infarction; Cardiac Function; Bradykinin/Nitric Oxide System; Intracellular Acidosis; Apoptosis; Inflammation; Tissue Regeneration; Late-Phase Postmyocardial Infarction; Cardiac Function; Cardiac Fibrosis; Cardiac Hypertrophy; Extracellular Matrix Degradation; Conclusion; References; Chapter 7: AT 2 R, Vascular Effects, and Blood Pressure; Introduction; AT 2 Vasorelaxation: In Vitro Preclinical Studies; Acute AT 2 R Vasodilatation/ BP Effects: In Vivo Preclinical Studies |
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Chronic AT 2 R Effects on BP: Preclinical StudiesHuman Vascular AT 2 R Function: Ex Vivo and In Vivo Studies; AT 2 R Vasorelaxation: Why Is There no Translation into Antihypertensive Effects in Chronic Studies?; Acknowledgments; References; Chapter 8: AT 2 R in Nervous System; Introduction; AT 2 R Expression in CNS ; AT 2 R Expression in Neuronal Injury; AT 2 R -Mediated Effects in CNS Cells; AT 2 R in Peripheral Neuronal Injury; AT 2 R Stimulation in Stroke; AT 2 R in Spinal Cord Injury; AT 2 R in Multiple Sclerosis; AT 2 R in Traumatic Brain Injury; Conclusion; References |
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Chapter 9: Roles of AT 2 R in Cognitive FunctionIntroduction; Preventive Effects of ARB on Cognitive Decline and Dementia; Protection Against Ischemic Brain Damage by AT 2 R Stimulation; Role of AT 2 R Stimulation in Cognitive Function; Role of AT 2 R-Associated Proteins in Cognitive Function; Conclusion; Acknowledgments; References; Chapter 10: The Protective Role of Angiotensin II (AT 2) Receptors in Renal Disease: Molecular Mechanisms and Indications ... ; Introduction; Renal AT 2 R Expression; Findings from AT 2 R Knockout (AT 2 KO) Mice; AT 2 R -Mediated Signaling Pathways |
| Summary |
The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin-angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1-7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (ScienceDirect, viewed April 30, 2015) |
| Subject |
Renin-angiotensin system.
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Renin-Angiotensin System
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MEDICAL -- Pharmacology.
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Renin-angiotensin system
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| Form |
Electronic book
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| Author |
Unger, Th., editor
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Steckelings, Ulrike M., editor
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Santos, Robson A. S. dos (Robson Augusto Souza dos), editor.
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| ISBN |
9780128014851 |
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0128014857 |
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