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Book Cover
Book
Author Sudbery, Peter, author

Title Human molecular genetics / Peter Sudbery and Ian Sudbery
Edition Third edition
Published Harlow, England ; New York : Pearson-Benjamin Cummings, 2009
©2009

Copies

Location Call no. Vol. Availability
 W'PONDS  611.01816 Sud/Hmg 2009  AVAILABLE
 MELB  611.01816 Sud/Hmg 2009  AVAILABLE
Description xiv, 445 pages, 2 unnumbered pages of plates : illustrations (some colour) ; 24 cm
Series Cell and molecular biology in action series
Cell and molecular biology in action.
Contents Preface -- 1. Human genetic disease -- Introduction -- Single-gene defects -- Multifactorial or complex disorders and traits -- Chromosomal mutations -- Mitochondrial mutations -- The Human Genome Project -- Summary -- 2. An introduction to the structure of the human genome -- Introduction -- Sequence architecture of the human genome -- Structure of chromosomes -- Summary -- 3. Mapping the human genome -- Introduction -- Sequence tagged sites : a common currency for the different types of map -- Genetic maps -- Physical maps -- An integrated physical and genetic map of the human genome -- Genome mapping is big science -- Summary -- 4. The sequence of the human genome -- Introduction -- Basic technology for sequencing the human genome -- The IHGSC clone-by-clone sequencing strategy -- The Celera shotgun sequencing -- Finishing the sequence -- Single nucleotide polymorphisms -- Annotating the sequence -- Sequencing other genomes -- Analysis of the human genome sequence -- Genomics -- The ENCODE Project -- Next-generation sequencing technologies -- Catalogues of somatic mutations -- Summary -- 5. Single-gene disorders -- Introduction -- Cloning disease genes -- Cystic fibrosis -- Duchenne muscular dystrophy -- Trinucleotide repeat expansion mutations -- Haemoglobinopathies -- Inherited predisposition to cancer -- Summary -- 6. The genetic components of complex diseases -- Introduction -- Evidence for a genetic component in complex disorders and phenotypic traits -- The genetic architecture of complex diseases -- Experimental approaches to identifying risk alleles -- Genome-wide association studies -- Case studies of complex diseases -- Summary -- 7. Small RNAs in human genetics -- Introduction -- Structure and function of microRNAs -- MicroRNA genomics -- MicroRNAs in human disease and diagnostics -- RNA interference -- RNAi screening to identify gene function and identifying drug targets -- Therapeutic RNAi -- The diversity of small RNAs -- Summary -- 8. Genetic testing -- Introduction -- Testing for known mutations -- Scanning genes for unknown mutations -- Summary -- 9. Gene therapy -- Introduction -- Types of gene therapy -- Methods of transferring transgenes into target cells -- Gene therapy for cystic fibrosis -- Progress and adverse events -- Summary -- 10. Human population genetics and evolution -- Introduction -- Basic principles in human population genetics -- Recent human evolution -- Disease frequencies in different populations -- Summary -- 11. DNA profiling in forensic criminology -- Introduction -- Current markers used for DNA profiling -- DNA databases -- Difficulties in the legal interpretation of DNA profiles -- Oversights of forensic DNA profiling -- Summary -- 12. Human genetics and society -- Introduction -- Genetic testing -- Human rights -- Patents -- Gene therapy -- Genetic determination -- Summary
Summary This third edition of 'Human molecular genetics' continues to provide a clear introduction to this complex and fast moving field. Now updated and revised throughout, the material covered has been carefully selected and structured to provide a concise overview for students studying the subject as part of a general biology, genetics or medical degree. The text is aimed at courses in Human Genetics, Human Molecular Genetics and The Molecular Basis of Disease taught within Biology, Biochemistry, Biomolecular Sciences, Biomedical Sciences, Genetics and medical and other health-care degrees
Notes "First published under the Addison Wesley Longman imprint 1998" -- title page verso
Bibliography Includes bibliographical references and index
Subject Human genetics.
Molecular genetics.
Human molecular genetics.
Genetics, Medical -- methods.
Genetic Diseases, Inborn.
Genome, Human.
Molecular Biology -- methods.
Author Sudbery, Ian, author
LC no. 2009009528
ISBN 9780132051576 (paperback)