| Description |
1 online resource |
| Contents |
Clathrin-Mediated Endocytosis / Alexander Sorkin, Manojkumar A. Puthenveedu -- Intimate and Facultative? Regulation of Clathrin-Mediated Endocytosis by the Actin Cytoskeleton / Tal Hirschhorn, Marcelo Ehrlich -- Oncogenic Signaling from the Plasma Membrane / Eli Zamir, Nachiket Vartak, Philippe I.H. Bastiaens -- Endocytosis in the Spatial Control of Polarised Cell Functions / Giorgio Scita, Andrea Disanza, Emanuela Frittoli -- Aberrant Vesicular Trafficking Contributes to Altered Polarity and Metabolism in Cancer / Shreya Mitra, Gordon B. Mills -- Endocytosis and the Regulation of Cell Signaling, Cell Adhesion, and Epithelial to Mesenchymal Transition in Cancer / Crislyn D'Souza-Schorey, Guangpu Li -- Efficient Enhancement of Signaling Capacity: Signaling Endosomes / Iwona Pilecka, Marta Miaczynska -- Nuclear Functions and Trafficking of Receptor Tyrosine Kinases / Ying-Nai Wang, Jennifer L. Hsu, Mien-Chie Hung -- Efficient Enhancement of Signalling Capacity: The Ubiquitin System / Daniela Hoeller, Ivan Dikic -- Molecular Mechanism of Ubiquitin-Dependent Traffic / Elena Maspero, Hans-Peter Wollscheid, Simona Polo -- Cbl as a Master Regulator of Receptor Tyrosine Kinase Trafficking / Ke Ma, Stephen C. Kales, Marion M. Nau, Stanley Lipkowitz -- Regulation of Endocytic Trafficking and Signalling by Deubiquitylating Enzymes / Han Liu, Sylvie Urbé, Michael J. Clague -- RTKs as Models for Trafficking Regulation: c-Met/HGF Receptor-c-Met Signalling in Cancer--Location Counts / Carine Joffre, Rachel Barrow, Ludovic Ménard -- Regulation of Epidermal Growth Factor Receptor Signaling by Endocytosis in Normal and Malignant Cells / Sergio Anastasi, Stefano Alemà, Oreste Segatto MD -- Stress-Driven Endocytosis of Tyrosine-Phosphorylated EGFR Leads to Tumorigenesis: The Critical Role of Oxidative Stress / Tzipora Goldkorn, Simone Filosto, Samuel Chung -- Internalisation, Endosomal Trafficking and Recycling of Integrins During Cell Migration and Cancer Invasion / Elena Rainero, Peter V.E. van den Berghe, Jim C. Norman -- Antibody-Mediated Receptor Endocytosis: Harnessing the Cellular Machinery to Combat Cancer / Gabi Tarcic, Yosef Yarden |
| Summary |
Endocytosis and vesicular trafficking determine the landscape of the cell's exterior, namely the density of surface molecules, such as receptors for growth factors and cytokines, adhesion molecules like integrins and cadherins, and a plethora of nutrient carriers. Hence, endocytosis is involved in signal transduction, cell adhesion and migration, as well as metabolism. To exploit these fundamental processes, malignancies subtly and multiply manipulate the endocytosis and the subsequent trafficking of protein cargoes. This is achieved by simultaneously altering the cytoskeleton, vesicle budding |
| Analysis |
Medicine |
|
Oncology |
|
Biochemistry |
|
Post-translational modification of proteins |
|
Cell receptors |
|
Cytology |
|
Biomedicine |
|
Cancer Research |
|
Cell Biology |
|
Receptors |
| Notes |
Includes index |
| Bibliography |
Cludes bibliographical references |
| Subject |
Cancer cells.
|
|
Endocytosis.
|
|
Neoplastic Cells, Circulating
|
|
Endocytosis
|
|
HEALTH & FITNESS -- Diseases -- Cancer.
|
|
MEDICAL -- Oncology.
|
|
Cancer cells
|
|
Endocytosis
|
| Form |
Electronic book
|
| Author |
Yarden, Y. (Yosef)
|
|
Tarcic, Gabi
|
| ISBN |
9781461465287 |
|
1461465281 |
|
1461465273 |
|
9781461465270 |
|
