| Description |
1 online resource (xviii, 390 pages) : illustrations |
| Contents |
Chapter 1 Introduction -- chapter 2 Two-Sided Tests: Introduction -- chapter 3 Two-Sided Tests: General Applications -- chapter 4 One-Sided Tests -- chapter 5 Two-Sided Tests with Early Stopping Under the Null Hypothesis -- chapter 6 Equivalence Tests -- chapter 7 Flexible Monitoring: The Error Spending Approach -- chapter 8 Analysis Following a Sequential Test -- chapter 9 Repeated Confidence Intervals -- chapter 10 Stochastic Curtailment -- chapter 11 General Group Sequential Distribution Theory -- chapter 12 Binary Data -- chapter 13 Survival Data -- chapter 14 Internal Pilot Studies: Sample Size Re-estimation -- chapter 15 Multiple Endpoints -- chapter 16 Multi-Armed Trials -- chapter 17 Adaptive Treatment Assignment -- chapter 18 Bayesian Approaches -- chapter 19 Numerical Computations for Group Sequential Tests |
| Summary |
Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis. These interim results may provide grounds for terminating the study-effectively reducing costs-or may benefit the general patient population by allowing early dissemination of its findings. Group sequential methods provide a means to balance the ethical and financial advantages of stopping a study early against the risk of an incorrect conclusion. Group Sequential Methods with Applications to Clinical Trials describes group sequential stopping rules designed to reduce average study length and control Type I and II error probabilities. The authors present one-sided and two-sided tests, introduce several families of group sequential tests, and explain how to choose the most appropriate test and interim analysis schedule. Their topics include placebo-controlled randomized trials, bio-equivalence testing, crossover and longitudinal studies, and linear and generalized linear models. Research in group sequential analysis has progressed rapidly over the past 20 years. Group Sequential Methods with Applications to Clinical Trials surveys and extends current methods for planning and conducting interim analyses. It provides straightforward descriptions of group sequential hypothesis tests in a form suited for direct application to a wide variety of clinical trials. Medical statisticians engaged in any investigations planned with interim analyses will find this book a useful and important tool |
| Bibliography |
Includes bibliographical references (pages 363-386) and index |
| Notes |
Print version record |
| Subject |
Clinical trials -- Statistical methods
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Search theory.
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Decision Theory
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Statistics as Topic -- methods
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Clinical Trials as Topic -- methods
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Models, Statistical
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MEDICAL -- Pharmacology.
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MEDICAL -- Biostatistics.
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Search theory
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Clinical trials -- Statistical methods
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Ensaios clínicos (pesquisa e planejamento)
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| Form |
Electronic book
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| Author |
Turnbull, Bruce W.
|
| ISBN |
0849303168 |
|
9780849303166 |
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9781584888581 |
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158488858X |
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9780367805326 |
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0367805324 |
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