| Description |
1 online resource (vii, 317 pages) : illustrations |
| Series |
Advances in experimental medicine and biology ; volume 1385 |
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Advances in experimental medicine and biology ; v. 1385.
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| Contents |
Intro -- Contents -- About the Editors -- Chapter 1: The Role of MicroRNAs in Cancer Biology and Therapy from a Systems Biology Perspective -- 1.1 Biological Facts About miRNA Biogenesis and Function -- 1.1.1 miRNA Biogenesis -- 1.1.2 miRNA Function -- 1.2 The Role of miRNAs in Cancer Progression, Diagnosis, and Therapy -- 1.2.1 Genome-Level Alterations in miRNAs -- 1.2.2 Oncogenic and Tumor-Suppressive miRNAs -- 1.2.3 miRNAs in Cancer Diagnostics and Therapy -- 1.3 miRNAs in Cancer Gene Regulatory Networks -- 1.3.1 miRNA Clusters: Groups of Similarly Regulated miRNAs |
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1.3.2 Target Hubs: Genes Regulated by Many miRNAs -- 1.3.3 miRNA Cooperativity: Synergistic Gene Regulation by Multiple miRNAs -- 1.3.4 Network Motifs: miRNA-Enriched Feedback and Feedforward Loops -- 1.4 Bioinformatics and Systems Approaches as the ̀̀Lifeline ́́to Navigate miRNA Networks -- References -- Chapter 2: Circulating MicroRNAs as Cancer Biomarkers in Liquid Biopsies -- 2.1 Introduction -- 2.2 Circulating miRNAs -- 2.3 Function of Circulating miRNAs -- 2.4 Circulating ncRNAs as Cancer Biomarkers -- 2.4.1 MiRNAs -- 2.4.2 LncRNAs and Other ncRNAs |
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2.5 Methods and Challenges to Detect Circulating miRNAs -- 2.6 Bioinformatics Analyses -- 2.6.1 Databases of miRNA: Target RNA Interaction -- 2.6.2 Databases of Transcription Factor: miRNA Gene Interaction -- 2.6.3 Construction of Regulatory Networks -- 2.6.4 Databases of miRNAs with Cancer Biomarker Potential -- 2.6.5 Application of Neural Networks and Meta-Analysis to Identify Robust Biomarkers -- 2.7 Conclusions -- References -- Chapter 3: Regulation of Immune Cells by microRNAs and microRNA-Based Cancer Immunotherapy -- 3.1 Introduction -- 3.2 Innate Immunity -- 3.2.1 Macrophages |
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3.2.2 Dendritic Cells -- 3.2.3 Natural Killer Cells -- 3.3 Adaptive [Acquired] Immunity -- 3.3.1 T-Helper Cells -- 3.3.2 Cytotoxic T Cells -- 3.3.3 Regulatory T Cells -- 3.4 miRNA-Mediated Regulation in the Tumor Microenvironment -- 3.5 Immune Checkpoint Molecules -- 3.6 miRNAs as Potential Targets for Immunotherapy -- 3.7 Challenges in miRNA-Based Therapy -- 3.8 Conclusions -- References -- Chapter 4: Machine Learning Based Methods and Best Practices of microRNA-Target Prediction and Validation -- 4.1 Introduction of miRNAs and Their Role in Cancer -- 4.2 miRNA Target Prediction Tools |
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4.2.1 Common Features for miRNA Target Prediction -- 4.2.2 Machine Learning Based Algorithms for miRNA Target Prediction -- 4.3 Best Practices for miRNA Target Prediction -- 4.3.1 Workflow to Detect miRNA-mRNA Target Sites -- 4.3.2 Validation of miRNA Target Prediction -- 4.4 miRNA-Based Therapeutics for Cancer -- References -- Chapter 5: Turning Data to Knowledge: Online Tools, Databases, and Resources in microRNA Research -- 5.1 Human miRNA Regulation -- 5.2 The Scope and Organization of the Chapter -- 5.3 Repositories for miRNA: Catalogs and Genome Browsers -- 5.3.1 miRNA Gene Catalogs |
| Summary |
This book provides an update on the latest development in the field of microRNAs in cancer research with an emphasis on translational research. Since the early 2000s, microRNAs have been recognized as important and ubiquitous regulators of gene expression. Soon it became evident that their deregulation can cause human diseases including cancer. This book focuses on the emerging opportunities for the application of microRNA research in clinical practice. In this context, computer models are presented that can help to identify novel biomarkers, e.g. in circulating microRNAs, and tools that can help to design microRNA-based therapeutic interventions. Other chapters evaluate the role of microRNAs in immunotherapy, immune responses and drug resistance. Covering key topics on microRNAs in cancer research this book is a valuable resource for both emerging and established microRNA researchers who want to explore the potential of microRNAs as therapeutic targets or co-adjuvants in cancer therapies |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed November 16, 2022) |
| Subject |
Cancer -- Genetic aspects -- Research
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MicroRNA -- Health aspects
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Systems biology.
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Systems Biology
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Cancer -- Genetic aspects -- Research
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Systems biology
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| Form |
Electronic book
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| Author |
Schmitz, Ulf, editor.
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Wolkenhauer, Olaf, 1966- editor.
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Vera-González, Julio, editor
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| ISBN |
9783031083563 |
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3031083563 |
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