Title Perfusion cell culture processes for biopharmaceuticals : process development, design, and scale-up / Moritz Wolf, Jean-Marc Bielser, Massimo Morbidelli

Published Cambridge, United Kingdom ; New York, NY : Cambridge University Press, 2020 ©2020

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Description 1 online resource (xv, 202 pages) : illustrations (some color) Series Cambridge series in chemical engineering Cambridge series in chemical engineering. Contents Perfusion mammalian cell culture for recombinant protein manufacturing -- Perfusion bioreactors : the set up and process characterization -- Scale-down models and sensors for process development -- Design and optimization of mammalian cell perfusion cultures -- Clinical and commercial scale reactors -- Mechanistic and statistical modeling of bioprocesses Summary This book is a monography about perfusion cell cultures for the production of biopharmaceuticals, such as therapeutic proteins (i.e. biomolecules like monoclonal antibodies), and describes the fundamentals, design and operation of these processes. Context is given in the first chapters to understand the state-of-the-art of the technology. We then give an overview of the challenges and objectives in operating mammalian cell perfusion cultures and provide guidelines for the design and setup of lab-scale bioreactor systems, and the required control structure to achieve stable operation. Scale-down devices and PAT tools are described in the context of continuous manufacturing and guidelines for process optimization are given using a variety of case studies to illustrate different approaches. Scale-up is also adressed with a strong focus on bioreactor aeration and mixing, shear stress and cell retention device. Finally, a general introduction for the application of mechanistic and statistic models in bioreactor process development and optimization is given in the last chapter. Provided by publisher Bibliography Includes bibliographical references and index Notes Description based on online resource; title from digital title page (viewed on July 23, 2020) Subject Cell culture. Perfusion (Physiology) Bioreactors. Biological products. Chemical models. Biologicals. Batch Cell Culture Techniques Perfusion -- methods Bioreactors Biological Products -- chemistry Models, Chemical Cells, Cultured Perfusion Biological Factors Biological Products Biologicals Biological products Bioreactors Cell culture Chemical models Perfusion (Physiology) Form Electronic book Author Wolf, Moritz, author. Bielser, Jean-Marc, author. LC no. 2020000229 ISBN 9781108847209 110884720X 9781108848077 1108848079

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