| Description |
1 online resource (xvii, 336 pages) : illustrations |
| Series |
Wiley series in probability and statistics |
|
Wiley series in probability and statistics.
|
| Contents |
Front Matter -- Introduction -- Fundamentals of Clinical Trials -- Frequentist versus Bayesian Statistics -- Phase I Trial Design -- Phase II Trial Design -- Phase III Trial Design -- Adaptive Randomization -- Late-Onset Toxicity -- Drug-Combination Trials -- Targeted Therapy Design -- References -- Author Index -- Subject Index -- Wiley Series in Probability and Statistics |
|
Fundamentals of clinical trials -- Frequentist versus Bayesian statistics -- Phase I trial design -- Phase II trial design -- Phase III trial design -- Adaptive randomization -- Late onset toxicity -- Drug combination trials -- Targeted therapy design |
| Summary |
There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. nevertheless, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. This book provides an overview of the fundamentals of clinical trials, the key terminologies and concepts, and a brief review and comparison on Bayesian and frequentist estimation and inference procedures. From the practical point of view, this book introduces various statistical methods that are commonly |
| Bibliography |
Includes bibliographical references and indexes |
| Notes |
Print version record |
| Subject |
Clinical trials -- Statistical methods
|
|
Bayesian statistical decision theory.
|
|
Mathematical statistics.
|
|
Clinical Trials as Topic -- methods
|
|
Bayes Theorem
|
|
Statistics as Topic -- methods
|
|
MEDICAL -- Laboratory Medicine.
|
|
Bayesian statistical decision theory
|
|
Clinical trials -- Statistical methods
|
|
Mathematical statistics
|
| Form |
Electronic book
|
| LC no. |
2011033589 |
| ISBN |
9781118183335 |
|
1118183339 |
|
9781118183304 |
|
1118183304 |
|
