NAFLD and insulin resistance (IR) -- Pathophysiology of NASH : insulin resistance, free fatty acids, and cytokines -- Adiponectin and NASH -- TNF-[alpha] and NAFLD/NASH -- Leptin and NAFLD/NASH -- Peroxisome proliferators-activated receptors (PPARs) and NAFLD/NASH -- Iron overload and NAFLD/NASH -- Mitochondrial abnormalities and NAFLD/NASH -- Genetic influences in NAFLD/NASH -- Therapeutic strategy for NASH patients -- Natural history of NAFLD -- Conclusions