| Description |
viii, 250 pages, 8 unnumbered pages of plates : illustrations (sime color) ; 24 cm |
| Contents |
Actinomycetes and antibiotics -- Antibiotic discovery and resistance -- Microbial sex -- Towards gene cloning -- From chromosome map to DNA sequence -- Bacteria that develop -- The switch to antibiotic production -- Unnatural natural products -- Functional genomics -- Genomics against TB and leprosy |
| Summary |
"Streptomyces in Nature and Medicine: The Antibiotic Makers is an insider's account of fifty years of genetic studies on the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, as well as anti-cancer, anti-parasitic, and immunosuppressant drugs." "The book begins by describing how these microbes - the actinomycetes - were discovered in the latter part of the nineteenth century, but remained a "Cinderella" group until the 1940s. The actinomycetes then shot to prominence with the discovery of streptomycin, the first effective treatment for tuberculosis and only the second antibiotic, alter penicillin, to become a medical marvel. Tempered by the rise of antibiotic resistance consequent on antibiotic misuse and overuse, a massive effort was made over the next several decades to find further treatments for infectious diseases and cancer."--BOOK JACKET |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Streptomyces -- Genetics.
|
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Streptomyces -- genetics.
|
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Genetic Engineering.
|
| LC no. |
2006005669 |
| ISBN |
9780195150667 alkaline paper |
|
019515066X alkaline paper |
|
