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Title Acute promyelocytic leukemia : a clinical guide / Oussama Abla, Francesco Lo Coco, Miguel A. Sanz, editors
Published Cham, Switzerland : Springer, [2018]


Description 1 online resource
Contents 880-01 Intro; Preface; Contents; Contributors; 1: History of Acute Promyelocytic Leukemia; Introduction; A Distinct Entity: "A Special Type of Leukemia" (1957-1987); The Clinical Description; A Controversy About Treatment; A Cytogenetic Signature; A New Paradigm: The Differentiation of Malignant Cells; Abolishing the Dogma of the Irreversible Status of Malignant Cells; An Experimental Approach; A Clinical Approach; All-Trans-Retinoic Acid as a Potential Candidate for Differentiation Therapy of APL; The Dinner that Initiated All-Trans-ƯRetinoic Acid Treatment for APL (1985); Hoops and Hurdles
880-01/(S The Case of APLImplications for Therapy; References; 4: Molecular Genetics of Acute Promyelocytic Leukemia; Introduction; PML-RARα/RARα-PML and Other APL Translocations in Leukemogenesis; Oncoprotein-Mediated Response to Therapy and Beyond; Retinoic Acid Signaling; Promyelocytic Leukemia Gene; References; 5: Acute Promyelocytic Leukemia Coagulopathy; Introduction; The Coagulopathy of APL; Clinical Manifestations; Hemostatic Abnormalities; Pathogenesis of the Coagulopathy of APL; Procoagulant Activity; Fibrinolytic and Proteolytic Properties; Cytokine Release and Adhesive Properties
No More ProductIs APL a Pseudo-Leukemia?; Early Relapses with ATRA; Hope for a Curable Disease; Worldwide Enthusiasm; New Clinical Horizons, Unknown Conditions; Nonstandard Regimens; Molecular Defects; First Attempts at Molecular Approaches; Clinical Consequences: Diagnostic and Follow-Up Tools; Toward a Biological Explanation of Oncogenesis and Restoration; Arsenic, a Manchurian Traditional Medicine (1995); A Second Era for Clinicians; A Better Biological Understanding; ATRA-ATO Combination in Patients: From Curable to Cured APL; And Beyond: Lessons and Questions; References
2: Molecular Targets of Treatment in Acute Promyelocytic LeukemiaIntroduction; The Translocation Partners: RARA and PML; The Oncoprotein PML/RARA; Therapeutic Effects of Retinoic Acid in APL; Uncoupling Differentiation and Loss of Clonogenicity Under RA Treatment; RA-Induced PML/RARA Degradation; Role of PML and p53 in the Cure of APL Under RA Treatment; Therapeutic Effects of Arsenic Trioxide in APL; ATO-Induced PML NB Reformation and PML/RARA Degradation; RA and ATO Synergy in APL Cure; References; 3: The Leukemic Stem Cell; The Cancer Stem Cell Theory; Defining Stemness in Leukemia
The Effects of ATRA and ATO on the Coagulopathy of APLManagement of the Coagulopathy; Platelet Transfusions, Heparin, and Antifibrinolytic Agents; References; 6: Early Death in Acute Promyelocytic Leukemia; Introduction; Definition and Timing of Early Death; Early Death in the Pre-ATRA Era; Early Death in Clinical Trials vs. Population-Based Studies; Causes of Early Death; Bleeding; Infections; Thrombosis; Differentiation Syndrome (DS); Organ Failure; Early Death Risk Factors; Role of ATRA in Early Death; Early Death over Time; Prevention of ED; References
Summary This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and children, while highlighting the most recent therapeutic recommendations for relapsed disease and the evolving indications for autologous and allogeneic stem cell transplant. This volume also features chapters focusing on secondary APL and therapy, late effects, rare presentations such as APL in the elderly and during pregnancy, and rare APL variants that may represent therapeutic challenges. Written by top experts in the field, Acute Promyelocytic Leukemia: A Clinical Guide is a valuable resource for clinicians and researchers who treat and investigate this disease in children and adults
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (EBSCO, viewed May 02, 2018)
Subject Acute myeloid leukemia.
Acute myeloid leukemia -- Treatment
Leukemia, Promyelocytic, Acute
Leukemia, Myeloid, Acute
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Acute myeloid leukemia
Form Electronic book
Author Abla, Oussama, editor.
Lo Coco, Francesco, editor
Sanz, Miguel A., editor
ISBN 9783319642574