| Description |
1 online resource (xiii, 181 pages) : illustrations (some color) |
| Contents |
Foreign DNA in Mammalian Systems; Preface; Contents; 1 Introduction; 2 ForeignDNA; 3 Methods to detect integrated foreign DNA; 4 The adenovirus paradigm; 5 Conclusions derived from a survey of junction sites; 6 Adenovirus-induced tumor cells and revertants; 7 Comparisons with other viral systems; Color plates; 8 Non-viral systems; 9 Patterns of DNA methylation in the human and in viral genomes; 10 Consequences of foreign DNA integration and persistence; 11 Uptake of foreign DNA from the environment: the gastrointestinal tract and the placenta as portals of entry |
| Summary |
It is unlikely that the established genomes of present day organisms remain stable forever. It is conceivable that foreign DNA can gain entry into individual cells of an organism. Foreign DNA is defined as genetic material that derives from another organism of the same or a different species. The natural environment is heavily "contaminated" with such foreign DNA, and mammals, like other organisms, are frequently exposed to foreign DNA in their environment, notably by ingesting their daily food supply. By necessity, the gastrointestinal tract also of all mammalian organisms is consta |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Adenoviruses.
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DNA.
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Genetic transformation.
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Mammals -- Genetics.
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Adenoviridae -- genetics.
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Cell Transformation, Viral -- genetics.
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DNA Methylation.
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DNA, Viral.
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Mammals -- genetics.
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Virus Integration.
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| Form |
Electronic book
|
| LC no. |
2001266996 |
| ISBN |
3527613463 |
|
3527613471 (electronic bk.) |
|
9783527613465 |
|
9783527613472 (electronic bk.) |
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