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Title ABC proteins : from bacteria to man / editors Ian Barry Holland [and others]
Edition 1st ed
Published Amsterdam ; Boston : Academic Press, ©2003


Description 1 online resource (xxiii, 647 pages) : illustrations (some color)
Contents Preface. -- Introduction. -- PART 1-PHYLOGENY AND EVOLUTION OF ABC-TRANSPORTERS -- Phylogenetic and Functional Classification of ABC (ATP-binding cassette) Systems -- Membrane Topology of the Human ABC Transporter Proteins -- Human and Drosophila ABC-Proteins -- PART 2-FUNDAMENTAL ASPECTS OF THE MECHANISM OF ACTION OF ABC-TRANSPORTERS -- Structure and Modular Organization of ABC-Transporters -- Substrate Binding Sites in ABC-Transporters -- Probing of Conformational Changes, Catalytic Cycle and ABC-Transporters Function -- X-ray Structure of an Intact ABC-Transporter, MsbA -- PART 3-PROKARYOTE ABC-TRANSPORTERS -- Introduction to Bacterial ABC-Transport Systems -- Import of Solutes by ABC-Transporters-The Maltose System -- Crystal Structures of Periplasmic Solute Binding Proteins in ABC-Transport Complexes Illuminate their Function -- Bacterial ABC-Transporters Involved in Protein Translocation -- Bacterial Multidrug Resistance Mediated by ABC-Transporters -- Structure and Function of Osmoregulated ABC Transporters -- PART 4 -NON-MAMMALIAN EUKARYOTE ABC-TRANSPORTERS -- Inventory & Evolution of Fungal ABC Protein Genes. -- Fungal ABC Proteins in Clinical Drug Resistance & Cellular Detoxification -- Drug Resistance Mediated by ABC Transporters in Parasites of Humans -- The Plant ABC Transporter Superfamily: the Functions of a Few and Identities of Many -- PART 5-MAMMALIAN MULTIDRUG RESISTANCE ABC-TRANSPORTERS -- Solving the Problem of Multidrug Resistance: ABC Transporters in Clinical Oncology -- Multidrug Resistance Protein 1 (ABCC1) -- MRP2, the Apical Export Pump for Anionic Conjugates -- The Multidrug Resistance Proteins 3-7 -- Lipid Transport by ABC Transporters -- Role of ABCA1 in Cell Turnover and Lipid Homeostasis -- Peroxisome ABC-Transporters -- ABC-Transporters in Mitochondria -- The Transporter Associated with Antigen Processing (TAP): A Peptide Transport and Loading Complex Essential for Cellular Immune Responses -- The Sulphonylurea Receptor: an ABCC Transporter that Acts as an Ion Channel Regulator -- ABC-Transporters and Human Eye Disease -- Structure Function Analysis of CFTR
Summary ABC Proteins is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications. It will be useful to anyone trying to stay abreast of the latest findings. This book is sure to become a classic and will regularly be updated. Key Features * Phylogeny and Evoloution of ABC Transporters * Fundamental Aspects of the Mechanism of Action of ABC Transporters * Prokaryote ABC Transporters * Non-Mammalian Transporters * Multidrug Transporters * ABC Transporters, Physiological Roles and Human Disease * Full color throughout
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject ATP-binding cassette transporters.
Carrier proteins.
Carrier Proteins
ATP-Binding Cassette Transporters
SCIENCE -- Life Sciences -- Biochemistry.
Carrier proteins
ATP-binding cassette transporters
ATP-binding cassette transporters.
Form Electronic book
Author Holland, I. B.
ISBN 0080481876