| Description |
1 online resource (xii, 318 pages) : illustrations |
| Contents |
Book Cover; Title; Contents; Preface; Contributors; Introduction to Adrenal Gland Involvement in Toxicology; An overview of adrenal gland involvement in toxicology: from target organ to stress and glucocorticosteroid modulation of toxicity; General Endocrinology, Pharmacology and Pathology of the Adrenal Gland Related to Species, Sex and Age and Glucocorticosteroid Actions; Adrenal morphology and hormone synthesis and regulation; Transport, actions and metabolism of adrenal hormones and pathology and pharmacology of the adrenal gland; Molecular and systems pharmacology of glucocorticosteroids |
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The Adrenal Gland as a Target OrganThe adrenal cortex as a toxicological target organ; The adrenal medulla as a toxicological target organ; Adrenocortical and Glucocorticosteroid Modulation of Toxicity; Glucocorticosteroid modulation of toxicity; Glucocorticosteroids: deleterious effects on neurons and potential exacerbation of environmental neurotoxicity; Glucocorticosteroids, stress and developmental toxicology; Glucocorticosteroids and immunotoxicity; Clinical Interfaces: Adrenal and Corticosteroid Involvement in Human Toxicology and Extrapolation to Man |
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Corticosteroid adverse effects and drug interactions in manAdverse drug reactions and the adrenal glands: a pharmacoepidemiological approach; Experimental adrenal toxicity: significance of findings and relevance to man; Index |
| Summary |
The adrenal gland is vitally important to health and secretes hormones that control many bodily processes ranging from normal metabolism to the response to stressful circumstances. The corticosteroid hormones are the basis for anti-inflammatory medicines and are very widely prescribed. Changes in the function of the adrenal gland, either naturally through stress or disease, or through the action of drugs and chemicals, can have a major impact on the body.; This text focuses on adrenal toxicity, examining how drugs and chemicals can directly and indirectly affect this gland. Coverage includes: classification of the types of adrenal and endocrine toxicity; the mechanistic and molecular basis of toxicity; reasons why the adrenal is the most common target organ in the endocrine system; drug toxicity specific to patients with adrenal disorders; drug- corticosteroid interactions; adverse drug reactions; and how the adrenal gland is vital in tolerance to toxic insult |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
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Print version record |
| Subject |
Endocrine toxicology.
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Adrenal glands -- Effect of chemicals on
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Glucocorticoids -- Mechanism of action
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Target organs (Anatomy)
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Adrenal Glands -- drug effects
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Adrenal Cortex Hormones -- physiology
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MEDICAL -- Endocrinology & Metabolism.
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Endocrine toxicology
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Glucocorticoids -- Mechanism of action
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Target organs (Anatomy)
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| Form |
Electronic book
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| Author |
Harvey, Philip W
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| LC no. |
96154634 |
| ISBN |
9780203482674 |
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0203482670 |
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9780748403301 |
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0748403302 |
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0203233069 |
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9780203233061 |
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128040552X |
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9781280405525 |
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9786610405527 |
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6610405522 |
|
1135746087 |
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9781135746087 |
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0429204426 |
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9780429204425 |
|
