This timely book provides a comprehensive overview of the latest developments in alphavirus research. Written by a team of prominent scientists the main focus is on the pathogenesis and host interactions. Topics covered include: genome structure and replication; viral evolution; laboratory diagnosis and detection; interaction with the interferon system; antiviral responses in mosquitoes; animal models of alphavirus-induced inflammatory disease; clinical manifestations of arthritogenic alphaviruses; encephalitic alphaviruses; the application of alphavirus vectors for gene therapy; and chikungun