| Description |
1 online resource (1 electronic resource (xvi, 250 pages, 16 unnumbered pages of plates)) : illustrations (some color) |
| Contents |
BACE : APP processing, and signal transduction in Alzheimer's disease / Dale E. Bredesen and Edward H. Koo -- Identification of BACE as a target in Alzheimer's disease / Robert L. Heinrikson and Sukanto Sinha -- BACE biological assays / Alfredo G. Tomasselli and Michael J. Bienkowski -- Peptidic, peptidomimetic, and HTS based BACE inhibitors / James P. Beck and Dustin J. Mergott -- Fragment-based approaches for identification of BACE inhibitors / Andreas Kuglstatter and Michael Hennig -- Structure-based drug design of BACE inhibitors : technical and practical aspects of preparation, 3-dimensional structure, and computational analysis / Felix F. Vajdos, Veerabahu Shanmugasundaram, and Alfredo G. Tomasselli -- Pharmacological models for preclinical testing : from mouse to dog to non-human primates / Jason L. Eriksen, Michael Paul Murphy, and Elizabeth Head -- Adsorption, distribution, metabolism, excretion (ADME), efficacy, and toxicology for BACE inhibitors / Ishrut Hussain and Emmanuel Demont -- Clinical trials for disease-modifying drugs such as BACE inhibitors / Henry H. Hsu -- Future strategies for development of novel BACE inhibitors : anti-APP B-site antibody and APP binding small molecule approaches for Alzheimer's disease / Beka Solomon [and others] |
| Summary |
BACE inhibitors and their use in the treatment of Alzheimer's Disease. BACE (ß-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Print version record |
| Subject |
Alzheimer's disease -- Chemotherapy
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Aspartic proteinases -- Inhibitors -- Therapeutic use
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Amyloid beta-protein precursor.
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Alzheimer Disease -- drug therapy
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Amyloid Precursor Protein Secretases -- pharmacology
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Amyloid Precursor Protein Secretases -- therapeutic use
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Amyloid beta-Protein Precursor
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MEDICAL -- Geriatrics.
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MEDICAL -- Nursing -- Gerontology.
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Alzheimer's disease -- Chemotherapy
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Amyloid beta-protein precursor
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| Form |
Electronic book
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| Author |
John, Varghese, 1958-
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| LC no. |
2009037093 |
| ISBN |
9780470594087 |
|
047059408X |
|
9780470594070 |
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0470594071 |
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128249175X |
|
9781282491755 |
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047029342X |
|
9780470293423 |
|
9786612491757 |
|
6612491752 |
|
