Title Bioactive peptides / edited by John Howl, Sarah Jones

Published Boca Raton : CRC Press, ©2009

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Description 1 online resource (xv, 479 pages, 8 unnumbered pages of plates) : illustrations (some color) Contents Angiotensins : from endocrine to intracrine functions / Mark C. Chappell -- CT, CGRP, amylin, and adrenomedullins / Debbie L. Hay and David R. Poyner -- Neuropeptide Y family peptides / Cláudia Cavadas, Joana Rosmaninho Salgado, and Eric Grouzmann -- Pituitary adenylate cyclase-activating polypeptide / Eve M. Lutz [and others] -- Opioid peptides / Jane V. Aldrich -- Cholecystokinins and gastrins / Jens F. Rehfeld -- The chemistry and biology of insulin-like peptide 3, a novel member of the insulin superfamily / Fazel Shabanpoor [and others] -- Somatostatin analogues / Kjell Öberg -- Tachykinins / Nigel M. Page, Parvathy Subramaniam, and Suzanne E. Newton -- Neurotensin / Paul R. Dobner and Robert E. Carraway Twenty-five years of galanin research / Johan Runesson [and others] -- Bioactive peptides in gut-brain signalling / Erik Näslund, Per Grybäck, and Per M. Hellström -- Nonribosomal peptides / Alexandra A. Roberts, Leanne A. Pearson, and Brett A. Neilan -- Anuran host-defense peptides that complex with Ca2+ calmodulin and inhibit the synthesis of the cell signalling agent nitric oxide by neuronal nitric oxide synthase / Jason R. Doyle [and others] -- Host-defense peptides from the secretion of the skin glands of frogs and toads : membrane-active peptides from the genera litoria, uperoleia, and crinia / John H. Bowie [and others] -- Antimicrobial peptides / Alison M. McDermott -- Mast cell degranulating peptides / Joseph A. Price -- Mastoparans / Sarah Jones and John Howl -- Spider venom and hemolymph-derived cytolytic and antimicrobial peptides / Lucia Kuhn-Nentwig, Christian Trachsel, and Wolfgang Nentwig Summary Focuses on Biology, Pharmacology, and Therapeutic ApplicationsThe study and diverse applications of bioactive peptides traverse many sub-disciplines within chemistry, biology, physics, and medicine. Answering a long-standing need, Bioactive Peptides focuses on the biology, pharmacology, and therapeutic applications of endogenous peptide mediators and their analogues. Moving peptide science beyond chemical synthesis strategies and into the realms of peptide biology and therapeutics, it presents the overall contribution that peptide science has made to molecular, cellular, and whole organism biology, while also discussing future targets and therapeutic applications. Beneficial for Experts and Novices AlikePart I provides details of bioactive peptides that interact with common drug targets and analyzes some of the most competitive areas of current research worldwide. While it is widely known that mammalian physiological systems utilize bioactive peptides that have yet to be discovered, other animals provide a rich and valuable source of bioactive peptides. This fascinating area of science is the theme of Part II. Parts III and IV investigate the unique bioactivities of various peptides that are ripe for further exploration. This definitive reference also includes:A detailed description and analysis of a broad range of peptides that interact with G protein-coupled receptors, the quantitatively dominant drug targetA discussion of non-ribosomal peptides, which hold promise as sources of endogenous mediatorsImportant examples of common methodologies employed to identify, characterize, and further develop bioactive peptides from a range of natural sourcesWith mounting worldwide interest in their therapeutic potential, bioactive peptides--includ Bibliography Includes bibliographical references and index Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL English John Howl, Sarah Jones digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL Print version record Subject Peptides -- Physiological effect Life sciences. Physical sciences. Physiology. Biological products. Biologicals. Biological Science Disciplines Amino Acids, Peptides, and Proteins Chemicals and Drugs Natural Science Disciplines Disciplines and Occupations Peptides Physiology Biological Factors Biological Products biological sciences. physical sciences. physiology. MEDICAL -- Biochemistry. MEDICAL -- Pharmacology. SCIENCE -- Life Sciences -- Cytology. Physiology Physical sciences Life sciences Biologicals Biological products Peptides -- Physiological effect Form Electronic book Author Howl, John. Jones, Sarah, Dr. ISBN 9780367802813 0367802813 9781420061161 142006116X

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