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Title Spectrums of amyotrophic lateral sclerosis : heterogeneity, pathology, and therapeutic directions / edited by Christopher A. Shaw and Jessica R. Morrice
Published Hoboken, NJ : Wiley-Blackwell, 2021
Online access available from:
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Description 1 online resource
Contents Clinical Heterogeneity of ALS -- Implications for Models and Therapeutic Development / Serena Lattante and Mario Sabatelli -- Genetic Basis of ALS / Jay P. Ross, Patrick A. Dion, and Guy A. Rouleau -- Susceptibility Genes and Epigenetics in Sporadic ALS / Jessica R. Morrice, Christopher A. Shaw -- The Lessons of ALS -- PDC -- Environmental Factors in ALS Etiology / Christopher A. Shaw and Thomas E. Marler -- The Microbiome of ALS -- Does It Start from the Gut? / Audrey Labarre and Alex Parker -- Protein Aggregation in Amyotrophic Lateral Sclerosis / Christen G. Chisholm, Justin J. Yerbury, and Luke McAlary -- Evidence for a Growing Involvement of Glia in Amyotrophic Lateral Sclerosis / Rowan A. W. Radford, Andres Vidal-Itriago, Natalie M. Scherer, Albert Lee, Manuel Graeber, Roger S. Chung, and Marco Morsch -- Animal Models of ALS -- Current and Future Perspectives / Robert A. D├ęziel, Amber L. Marriott, Denis G. Kay, and Daphne A. Gill -- Clinical Trials in ALS -- Current Challenges and Strategies for Future Directions / Kristiana Salmon and Angela Genge -- Future Priorities and Directions in ALS Research and Treatment / Jessica R. Morrice, Michael Kuo, and Christopher A. Shaw
Summary "Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disorder affecting both upper and lower motor neurons. Based on age at onset, site of onset, disease duration, and relative predominance of upper or lower motor neuron signs, clinical manifestations of ALS are very heterogeneous, and different clinical subtypes may be delineated. Although ALS has long been considered a paradigm of pure motor neuron disorder, it has recently been linked to other neurological diseases. Clinical, genetic, and/or neuropathological overlap exists with frontotemporal dementia, distal myopathies, psychiatric disorders, and extrapyramidal syndromes. This clinical heterogeneity can depend on the pleiotropy of ALS-associated genes and by the oligogenic model of disease mechanism. A number of animal models have been created, each of them recapitulating some clinical and neuropathological features of patients. More recently, induced pluripotent stem cells have been used, directly derived from affected patients with different genetic mutations. The combination of animal and cellular models represents an advanced tool that can help to functionally characterize the pathogenetic mechanisms underlying the disease and specifically find efficient and personalized drugs to treat ALS patients"-- Provided by publisher
Bibliography Includes bibliographical references and index
Notes Description based on print version record and CIP data provided by publisher; resource not viewed
Subject Amyotrophic Lateral Sclerosis -- genetics
Amyotrophic Lateral Sclerosis -- drug therapy
Genetic Heterogeneity
Models, Genetic
Spectrum Analysis
Amyotrophic lateral sclerosis -- Chemotherapy
Amyotrophic lateral sclerosis -- Genetic aspects
Form Electronic book
Author Morrice, Jessica R., editor.
Shaw, Christopher A. (Christopher Ariel), editor.
LC no. 2021003407
ISBN 1119745500
1119745519
1119745535
9781119745501
9781119745518
9781119745532