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Title Genetic disorders of endocrine neoplasia / volume editors, P.L.M. Dahia, C. Eng
Published Basel ; New York : Karger, ©2001


Description 1 online resource (viii, 218 pages) : illustrations
Series Frontiers of hormone research ; vol. 28
Frontiers of hormone research ; v. 28.
Contents Hereditary endocrine neoplasias : fundamental insights and the practice of clinical cancer genetics / P.L.M Dahia, C. Eng -- Identification and characterization of disease-related genes : focus on endocrine neoplasias / R.C.T. Aguiar, P.L.M. Dahia -- Clinical and molecular aspects of multiple endocrine neoplasia type 1 / S.C. Chandrasekharappa, B. Tean Teh -- Multiple endocrine neoplasia type 2 : molecular aspects / L.M. Mulligan -- Multiple endocrine neoplasia type 2 : clinical aspects / O. Gimm -- Von Hippel-Lindau disease : genetic and clinical observations / O. Iliopoulos -- Hamartoma and lentiginosis syndromes : clinical and molecular aspects / D.J. Marsh, C.A. Stratakis
Summary The genetics of endocrine cancers is clearly an area where new scientific discoveries that have occurred in the past few years have already been translated into clinical practice. This volume attempts to provide a state-of-the-art review of some of the most relevant inherited syndromes that share a higher susceptibility to the development of endocrine tumors. It focuses on familial tumor syndromes for which the primary gene defect has been well characterized or recently identified. An overview of cloning strategies and gene characterization in cancer, is combined with detailed discussions of clinical aspects and molecular features of heritable endocrine neoplastic diseases, such as MEN1 and MEN2 and Von Hippel-Lindau disease. Studies on the PTEN gene, the first known phosphatase to lead to cancer when disrupted are discussed in detail. Also included disrupted is the recent identification and partial characterization of one of at least two genes for Carney Complex, PRKARIA. The authors place special emphasis on testing and screening strategies which now allow a much earlier identification of family members at risk. The challenge for the 21st century will be to develop equal progress in pharmacological prevention and cure based on the knowledge of the function of these susceptibility genes and their targets
Bibliography Includes bibliographical references and index
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Print version record
Subject Endocrine glands -- Cancer -- Genetic aspects
Endocrine Gland Neoplasms -- genetics
Multiple Endocrine Neoplasia -- genetics
Endocrine glands -- Cancer -- Genetic aspects.
Multiple endokrine Adenopathie -- Erbkrankheit -- Molekulargenetik -- Aufsatzsammlung.
Erbkrankheit -- Multiple endokrine Adenopathie -- Molekulargenetik -- Aufsatzsammlung.
Molekulargenetik -- Erbkrankheit -- Multiple endokrine Adenopathie -- Aufsatzsammlung.
Angiomatosis retinae -- Erbkrankheit -- Molekulargenetik -- Aufsatzsammlung.
Erbkrankheit -- Angiomatosis retinae -- Molekulargenetik -- Aufsatzsammlung.
Molekulargenetik -- Erbkrankheit -- Angiomatosis retinae -- Aufsatzsammlung.
Form Electronic book
Author Dahia, P. L. M. (Patricia L. M.)
Eng, Charis, 1962-
ISBN 9783318006810