| Description |
1 online resource |
| Contents |
Intro -- Preface -- Acknowledgments -- Contents -- Chapter 1: Historical Background of the Mongolian Gerbil in Research -- 1.1 Introduction -- 1.2 Historical Background -- 1.2.1 The Gerbil as a Model to Study Brain Ischemia -- 1.2.2 The Gerbil as a Model to Study Epilepsy -- 1.2.3 The Use of the Mongolian Gerbil in Medical Research -- 1.2.3.1 The Growth and Aging of the Gerbil -- 1.2.3.2 Papers Related to Gerbil's Brain Vasculature -- 1.2.3.3 Effects of Ischemia of the Hippocampus and Brain Physiology -- 1.2.3.4 Effects of Cerebral Ischemia on Various Body Functions -- References |
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Chapter 2: Brain Energy Metabolism and Mitochondrial Function -- 2.1 Introduction -- 2.2 The Discovery of Oxygen -- 2.3 The Discovery of Mitochondria -- 2.4 Monitoring of Brain Mitochondrial Function In Vivo -- References -- Chapter 3: Brain Real-Time Monitoring Techniques Used in Mongolian Gerbils -- 3.1 Introduction -- 3.2 Monitoring of NADH in the Cerebral Cortex of Gerbils -- 3.2.1 Introduction -- 3.2.2 Methods -- 3.2.3 Results and Discussion -- 3.3 Simultaneous Monitoring of NADH In Vivo Together with Extracellular K+, DC Steady Potential, and ECoG |
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3.4 Monitoring of Brain NADH Together with Tissue pO2 and ECoG -- 3.5 Bilateral Monitoring of NADH and ECoG Under Ischemia -- 3.6 The First Multiparametric Assembly for Recording of NADH, Extracellular K+, H+, DC Steady Potential, and ECoG -- 3.6.1 Electrode Assembly -- 3.6.2 Correction for Local DC Biopotential -- 3.6.3 NADH Fluorescence Measurement -- 3.7 Multisite Monitoring of NADH in Gerbils Under Various Conditions -- 3.8 Responses to Ischemia In Vivo and Freeze-Trapped Redox Scanning of the Gerbil Brain -- 3.8.1 In Vivo Surface Fluorometry/Reflectometry |
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3.8.2 Frozen Brain Redox State Evaluation -- 3.8.3 Gerbil Preparation -- 3.8.4 Funnel Freezing of the Brain -- 3.8.5 Typical Results in One Gerbil -- 3.9 Simultaneous Real-Time Monitoring of Brain NADH, pO2, ECoG, DC Potential, and Extracellular K+ -- 3.9.1 The Multiprobe Assembly -- 3.9.2 Preparation of Electrodes -- 3.9.3 Typical Results -- 3.10 Simultaneous Real-Time Monitoring of Brain NADH, HbO2, ECoG, DC Potential, Extracellular K+ and Ca2+ -- 3.10.1 Introduction -- 3.10.2 Multiprobe Assembly -- 3.10.3 NADH Fluorescence Measurement -- 3.10.4 Hemoglobin Spectrophotometry |
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3.10.5 Typical Result -- 3.11 Simultaneous Real-Time Monitoring of Brain NADH, CBF, ECoG, DC Potential, Extracellular K+ and Ca2+ -- 3.11.1 Multiprobe Assembly -- 3.11.2 Animal Preparation -- 3.11.3 Typical Results -- 3.12 Simultaneous Monitoring of Brain NADH, CBF, ECoG, DC Potential, Extracellular K+, Na+, Ca+2, and H+ -- 3.12.1 Introduction -- 3.12.2 Methods -- 3.12.2.1 Multiprobe Assembly -- 3.12.2.2 Relative Cerebral Blood Flow (RCBF) -- 3.12.2.3 NADH Redox State Fluorometry -- 3.12.2.4 Typical Result |
| Summary |
The Mongolian gerbil brain lies in the anatomy of the blood vessels supplying blood to the brain. In all mammals, there is a special mechanism that compensates for the decreased blood flow to the brain in the case of development of stroke. This mechanism is missing in the gerbil and therefore makes the Mongolian gerbil a unique model for stroke. Dr. Mayevsky adopted the gerbil as a model for stroke and his laboratory uniquely studied the mitochondria in the gerbil brain under various pathophysiological conditions. This book describes the history of the Mongolian gerbil in research, the brain energy metabolism and mitochondrial function and brain real-time monitoring systems used in gerbils, as well as the brain vasculature of the Mongolian gerbil. Further, the book includes chapters on brain multisite recording under brain perturbations, multiparametric responses to brain activation, and the effect of neuroprotectants on the gerbil brain. This is an ideal book for research teams researching stroke and epilepsy |
| Subject |
Brain -- Pathophysiology -- Animal models
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Mongolian gerbil.
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| Form |
Electronic book
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| ISBN |
9783031695490 |
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3031695496 |
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