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Title Biologic and gene therapy of autoimmune disease / volume editor, C.G. Fathman
Published Basel ; New York : Karger, 2000


Description 1 online resource (223 pages) : illustrations
Series Current directions in autoimmunity, 1422-2132 ; vol. 2
Current directions in autoimmunity ; v. 2.
Contents Contents -- Oral Tolerance as a Treatment Modality for Autoimmune Diseases -- Anti- CD4 Monoclonal Antibody Therapy in Human Autoimmune Diseases -- Novel Concepts of Tumor Necrosis Factor Action in Autoimmune Pathology -- Anti- TNFa Therapy in Rheumatoid Arthritis Current and Future Directions -- Cytokine- Directed Targeting in Chronic Arthritis -- Interleukin- 10: Therapeutic Prospects in Rheumatoid Arthritis -- Immunomodulation of Crohn s Disease -- Retroviral and Lentiviral Gene Therapy for Autoimmune Disease -- Application of Gene Therapy in Autoimmune Disease
DNA Vaccination in the Treatment of Autoimmune DiseaseAuthor Index -- Subject Index
Summary The clinical management of autoimmune diseases has proven to be extremely difficult. Current therapies focus on trying to alleviate symptoms, but fail to correct the fundamental immune defects that lead to pathology. To achieve this goal, it is necessary to understand much of the biology of antigen presentation, lymphocyte activation and the effects of cytokines. The articles in this book provide an up-to-date review of current innovative therapies using both biologic and gene therapy for the treatment of selected autoimmune diseases. Therapeutical approaches discussed include oral tolerance, the use of anti-CD4 monoclonal antibodies, IL-10 and anti-TNFa antibodies, DNA vaccination, and gene therapy applied to organ-specific autoimmune disease. Although some of these techniques are still in their infancy, their potential efficacy has been demonstrated in several animal models of autoimmune disease, holding great promise for the future development of treatments. Written by recognized experts in the field, the chapters in this book illustrate the concept of technology transfer from bench to bedside and provide a valuable update for clinicians and scientists in clinical immunology
Bibliography Includes bibliographical references and indexes
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
Print version record
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Subject Autoimmune diseases -- Genetic aspects
Autoimmune diseases -- Treatment
Biological response modifiers -- Therapeutic use
Gene therapy.
Gene therapy -- Methodology
Autoimmune diseases -- Therapeutic use
Autoimmune Diseases -- therapy
Genetic Therapy
Biological Therapy -- methods
Genetic Therapy -- methods
Autoimmune diseases -- Genetic aspects
Autoimmune diseases -- Treatment
Biological response modifiers -- Therapeutic use
Gene therapy
Maladies auto-immunes -- Thérapeutique.
Biothérapie -- Méthodes.
Thérapie génique -- Méthodes.
Maladies autoimmunes -- Aspect génétique.
Form Electronic book
Author Fathman, C. Garrison
ISBN 9783318004908