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Title Apoptosis and its relevance to autoimmunity / volume editor, Keith B. Elkon
Published Basel ; New York : Karger, ©2006


Description 1 online resource (vii, 210 pages) : illustrations (some color)
Series Current directions in autoimmunity, 1422-2132 ; v. 9
Current directions in autoimmunity ; v. 9. 1422-2132
Contents Death receptor signaling and its function in the immune system / Fas, S.C. [and others] -- Inherited and acquired death receptor defects in human autoimmune lymphoproliferative syndrome / Rieux-Laucat, F. -- Tumor necrosis factor ligand-receptor superfamily and arthritis / Hsu, H.-C., Wu, Y., Mountz, J.D. -- Mitochondria, apoptosis and autoimmunity / Pinkoski, M.J., Waterhouse, N.J., Green, D.R. -- Role of Bim and other Bcl-2 family members in autoimmune and degenerative diseases / Hughes, P., Bouillet, P., Strasser, A. -- Mitochondria, cell death, and B cell tolerance / Deming, P.B., Rathmell, J.C. -- Role of complement and other innate immune mechanisms in the removal of apoptotic cells / Ogden, C.A., Elkon, K.B. -- Collections: opsonins for apoptotic cells and regulators of inflammation / Stuart, L.M., Henson, P.M., Vandivier, R.W. -- MFG-E8-dependent clearance of apoptotic cells, and autoimmunity caused by its failure / Hanayama, R. [and others] -- Clearance of apoptotic cells in human SLE / Gaipl, U.S. [and others] -- Apoptosis and glomerulonephritis / Watson, S. [and others]
Summary Over the last 15 years, apoptosis has become a dominant focus of medical research in the field of immunology. This publication discusses the three major areas of apoptosis research: extrinsic death receptor pathways, intrinsic cell death pathways and the mechanisms responsible for apoptotic cell clearance. Each section delineates the proteins and signal transduction pathways and describes genetic alterations that lead to autoimmune diseases. Although most cell death abnormalities have been associated with systemic autoimmune disorders such as lupus erythematosus and lymphoproliferative syndrom
Bibliography Includes bibliographical references and indexes
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
Print version record
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Subject Apoptosis.
Autoimmune diseases.
Natural immunity.
Apoptosis -- immunology
Autoimmune Diseases
Autoimmune Diseases -- physiopathology
Autoimmune Lymphoproliferative Syndrome
Autoimmunity -- physiology
Immunity, Innate
Receptors, Immunologic -- physiology
MEDICAL -- Immunology.
Natural immunity
Autoimmune diseases
Apoptosis -- Autoimmunität -- Aufsatzsammlung.
Autoimmunität -- Apoptosis -- Aufsatzsammlung.
Form Electronic book
Author Elkon, Keith B
ISBN 142379690X