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Title B cell biology in autoimmunity / volume editor, David Nemazee
Published Basel ; New York : Karger, ©2003


Description 1 online resource (viii, 272 pages) : illustrations
Series Current directions in autoimmunity, 1422-2132 ; v. 6
Current directions in autoimmunity ; v. 6. 1422-2132
Contents B cell anergy and systemic lupus erythematosus -- BLyS and B cell autoimmunity -- Apoptosis and B cell tolerance -- Signaling mutations and autoimmunity -- Abnormal B cell signal transduction in systemic lupus erythematosus -- Toll-like receptors and activation of autoreactive B cells -- Affinity maturation and autoimmunity to DNA -- Role of complement in the development of autoimmunity -- Rheumatoid factors in health and disease: structure, function, induction and regulation -- Development of VH11+ B cells: a model for selection of B cells producing natural autoantibodies -- The role of B lymphocytes as key antigen-presenting cells in the development of T cell-mediated autoimmune Type 1 diabetes -- The chronic graft-versus-host model of systemic autoimmunity -- Do B cells take advantage of 'missing self' recognition?
Summary B cells play a central role not only in adaptive immunity, but also in autoimmunity. To understand how B cells are normally prevented from reacting to self-tissue, what goes wrong in autoimmunity, and how B cells contribute to it is the aim of this book. This volume includes more than a dozen in-depth reviews by researchers specializing in various aspects of basic B cell biology that have relevance to autoimmune diseases. These up-to-date chapters present the latest information on B cell signal transduction, apoptosis, genetics and molecular biology. Also featured are chapters with special reference to particular autoimmune diseases in which B cells have been shown to play a critical role, such as type 1 diabetes, chronic graft-versus-host disease and lupus erythematosus. Further topics covered include the role of the complement system, rheumatoid factors, and anti-DNA autoantibodies as well as important related areas such as natural autoantibodies, B cell immune tolerance, Toll receptor signaling, and the immunobiology of BAFF/BLyS. Both basic researchers and clinician scientists who wish to understand the role of B lymphocytes in immune tolerance and autoimmunity will benefit from this timely publication
Bibliography Includes bibliographical references and indexes
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Print version record
Subject B cells.
Autoimmunity -- physiology
B-Lymphocytes -- immunology
B cells
B-Lymphozyt -- Autoimmunität -- Aufsatzsammlung.
Autoimmunität -- B-Lymphozyt -- Aufsatzsammlung.
Autoaggressionskrankheit -- B-Lymphozyt -- Aufsatzsammlung.
B-Lymphozyt -- Autoaggressionskrankheit -- Aufsatzsammlung.
Form Electronic book
Author Nemazee, David Ahmad
ISBN 9783318008739