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Book Cover

Title Medicinal Chemistry of Drugs Affecting the Nervous System
Published Singapore : Bentham Science Publishers, 2020


Description 1 online resource (406 p.)
Series Medicinal Chemistry for Pharmacy Students Ser
Medicinal Chemistry for Pharmacy Students Ser
Contents Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Preface -- List of Contributors -- Drugs Affecting the Cholinergic System -- Cory R. Theberge1, Kim Lindsey-Goodrich2 and Ashok E. Philip3,* -- HISTORICAL PERSPECTIVES -- INTRODUCTORY CONCEPTS -- Choline and Acetylcholine -- Acetylcholine and Neurotransmission -- Cholinergic Neurochemistry: ACh Biosynthesis, Storage, Release, and Metabolism -- Cholinergic Receptors -- Muscarinic and Nicotinic Subtypes -- Clinical Use of Acetylcholine -- MUSCARINIC RECEPTOR AGONISTS -- MUSCARINIC RECEPTOR ANTAGONISTS (ANTICHOLINERGICS)
Donepezil (Aricept®) -- Pharmacokinetics -- Side effects/Drug Interactions -- Rivastigmine (Exelon®) 2000, Oral -- 2008, Patch -- Pharmacokinetics -- Side effects/Drug Interactions -- Galantamine (Razadyne®) 2001 -- Pharmacokinetics -- Side effects/Drug-interactions -- NMDA Receptor Antagonist: Memantine (Namenda®) 2003 -- Pharmacokinetics -- Side effects/Drug interactions -- Place in Therapy -- CASE STUDY -- What therapeutic modifications would you make at this time and why? -- Drug Discovery Case Study -- The Quaternary Advantage -- Ipratropium and the Kinetic Selectivity of Tiotropium
STUDENT SELF STUDY GUIDE -- PRACTICE QUESTIONS -- NOTES -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Drugs Affecting Adrenergic System -- M. O. Faruk1,* and Les Ramos2 -- HISTORICAL BACKGROUND -- THE INTRODUCTORY CONCEPTS -- Adrenergic Neurotransmitters -- Adrenergic Receptors (ARs) -- DRUGS AFFECTING ADRENERGIC SYSTEM: STRUCTURES, ACTIVITY, METABOLISM AND RELATED THERAPEUTIC CONSIDERATIONS -- The Antiadrenergics Affecting Synthesis, Storage, or Release of NE (Fig. 7) -- Metyrosine -- Reserpine -- Mechanism of Action -- Pharmacokinetics
Summary The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set serves as a reference guide to pharmacists on aspects of the chemical basis of drug action. Medicinal Chemistry of Drugs Affecting the Nervous System is the second volume of the series and it presents 8 chapters focusing on a comprehensive account of drugs affecting the nervous system. The volume informs readers about the medicinal chemistry of relevant drugs, which includes the mechanism of drug action, detail structure activity relationships and metabolism as w
Notes Description based upon print version of record
Subject Neuropharmacology.
Autonomic nervous system -- Effect of drugs on
Central nervous system -- Effect of drugs on
Pharmaceutical chemistry.
Chemistry, Pharmaceutical
Central nervous system -- Effect of drugs on
Pharmaceutical chemistry
Form Electronic book
Author Faruk, M. O
Philip, Ashok E
ISBN 9811454078