| Description |
1 online resource (viii, 272 pages) : illustrations |
| Series |
Current directions in autoimmunity, 1422-2132 ; v. 6 |
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Current directions in autoimmunity ; v. 6. 1422-2132
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| Contents |
B cell anergy and systemic lupus erythematosus -- BLyS and B cell autoimmunity -- Apoptosis and B cell tolerance -- Signaling mutations and autoimmunity -- Abnormal B cell signal transduction in systemic lupus erythematosus -- Toll-like receptors and activation of autoreactive B cells -- Affinity maturation and autoimmunity to DNA -- Role of complement in the development of autoimmunity -- Rheumatoid factors in health and disease: structure, function, induction and regulation -- Development of VH11+ B cells: a model for selection of B cells producing natural autoantibodies -- The role of B lymphocytes as key antigen-presenting cells in the development of T cell-mediated autoimmune Type 1 diabetes -- The chronic graft-versus-host model of systemic autoimmunity -- Do B cells take advantage of 'missing self' recognition? |
| Summary |
B cells play a central role not only in adaptive immunity, but also in autoimmunity. To understand how B cells are normally prevented from reacting to self-tissue, what goes wrong in autoimmunity, and how B cells contribute to it is the aim of this book. This volume includes more than a dozen in-depth reviews by researchers specializing in various aspects of basic B cell biology that have relevance to autoimmune diseases. These up-to-date chapters present the latest information on B cell signal transduction, apoptosis, genetics and molecular biology. Also featured are chapters with special reference to particular autoimmune diseases in which B cells have been shown to play a critical role, such as type 1 diabetes, chronic graft-versus-host disease and lupus erythematosus. Further topics covered include the role of the complement system, rheumatoid factors, and anti-DNA autoantibodies as well as important related areas such as natural autoantibodies, B cell immune tolerance, Toll receptor signaling, and the immunobiology of BAFF/BLyS. Both basic researchers and clinician scientists who wish to understand the role of B lymphocytes in immune tolerance and autoimmunity will benefit from this timely publication |
| Bibliography |
Includes bibliographical references and indexes |
| Notes |
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL |
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digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL |
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Print version record |
| Subject |
B cells.
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Autoimmunity.
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Autoimmunity -- physiology
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B-Lymphocytes -- immunology
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B-Lymphocytes
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Autoimmunity
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Autoimmunity
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B cells
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B-Lymphozyt -- Autoimmunität -- Aufsatzsammlung.
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Autoimmunität -- B-Lymphozyt -- Aufsatzsammlung.
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Autoaggressionskrankheit -- B-Lymphozyt -- Aufsatzsammlung.
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B-Lymphozyt -- Autoaggressionskrankheit -- Aufsatzsammlung.
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| Form |
Electronic book
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| Author |
Nemazee, David Ahmad
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| ISBN |
9783318008739 |
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3318008737 |
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9783805591331 |
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3805591330 |
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