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Title Protein aggregation in bacteria : functional and structural properties of inclusion bodies in bacterial cells / edited by Silvia Maria Doglia, Marina Lotti
Published Hoboken, New Jersey : Wiley, [2014]


Description 1 online resource
Contents Fundamentals of protein folding / Vladimir N. Uversky -- Recruiting unfolding chaperones to solubilize misfolded recombinant proteins / Rayees U.H. Mattoo and Pierre Goloubinoff -- Osmolytes as chemical chaperones to use in protein biotechnology / Ario De Marco -- Inclusion bodies in the study of amyloid aggregation / Anna Villar-Piqu and Salvador Ventura -- Protein aggregation in unicellular eukaryotes / Marina Caldara, Joris Winderickx and Vanessa Franssens -- Structural properties of inclusion bodies / Antonino Natalello, Diletta Ami, Silvia Maria Doglia -- Residue-specific structure of proteins in inclusion bodies / Christian Wasmer, Marielle Wlti, Yongli Chen, Lei Wang -- Biomedical applications of bacterial inclusion bodies / Imma Ratera, Spela Peternel, Joaquin Seras-Franzoso, Olivia Cano-Garrido, Elena Garcia-Fruitcents, Rafael Cubarso, Esther Varquez, Jose Luis Corchero, Escarlata Rodriguez-Carmona, Jaume Veciana, Antonio Villaverde -- Aggregation of recombinant proteins : understanding basic issues to overcome production bottlenecks / Marina Lotti and Loredano Pollegioni -- Fusion to a pull-down module : designing enzymes to form biocatalytically active insoluble aggregates / Bernd Nidetzky
Summary This book focuses on the aggregation of recombinant proteins in bacterial cells in the form of inclusion bodies. Recent reports revolutionized the current view of inclusion bodies from that of inert deposits of inactive proteins to reservoirs of proteins that can eventually maintain biological activity and/or be rescued by cells. Aggregation is put in the context of updated knowledge about the folding and aggregation of proteins in simple cells and new perspectives derived from the application of this knowledge are presented. The following topics are addressed: a) molecular and c
Bibliography Includes bibliographical references and index
Notes Print version record and CIP data provided by publisher
Subject Bacterial proteins -- Physiology
Bacterial proteins -- Therapeutic use
Industrial microbiology -- Methods
Inclusion Bodies -- physiology
Bacterial Proteins -- chemistry
Bacterial Proteins -- physiology
Bacterial Proteins -- therapeutic use
Inclusion Bodies -- chemistry
Industrial Microbiology -- methods
SCIENCE -- Life Sciences -- Biochemistry.
Bacterial proteins
Form Electronic book
Author Doglia, Silvia Maria, editor.
Lotti, Marina, editor.
LC no. 2013051094
ISBN 9781118801529