| Description |
1 online resource (xx, 778 pages) |
| Series |
Collaborative bioethics ; volume 2 |
|
Collaborative bioethics ; v. 2.
|
| Contents |
Intro -- Foreword -- Acknowledgments -- Contents -- Editors and Contributors -- Contributors -- Chapter 1: Introduction: Biomedical Research in One World: Current and Future Challenges -- References -- Part I: Biomedical Research: Genetic and Cell Research -- Chapter 2: Learning from Icarus: The Impact of CRISPR on Gene Editing Ethics -- Introduction -- Brief History of Gene Editing and CRISPR -- What Is Ethically Unique About CRISPR? -- Who Owns CRISPR, and Does This Matter? -- Technical Concerns, Risks, and Benefits -- Transparency and Public Deliberation -- Informed Consent -- Playing God -- Solidarity and Justice -- Conclusion -- References -- Chapter 3: Bioethical Decision Making and Genome Editing -- Introduction -- Determining the Ethical Challenges for Human Beings -- Safety Concerns -- Distinguishing Different Personal Identities -- Non-heritable Genome Editing -- Heritable Genome Editing -- Advantages of Heritable Genome Editing -- Disadvantages of Heritable Genome Editing -- Decision-Making in a Practical Context -- Gene Editing of Very Early Embryos -- Genome Editing of Sperm, Eggs, and During Fertilisation -- On What Basis Should a Decision Be Made? -- Conclusion -- References -- Chapter 4: Therapeutic Genome Editing -- References -- Chapter 5: Bioethical Decision-Making About Somatic Cell Genome Editing: Sickle-Cell Disease as a Case Study -- Introduction -- What Are Somatic Cells? -- Somatic Cells and Disease Etiology -- Monogenic and Polygenic Diseases -- Historical Development of Somatic Cell Genome Editing -- Homologous Recombination -- Non-homologous End-Joining -- Nuclease-Mediated SCGE -- Ex Vivo, In Vivo and In Utero Applications of SCGE -- Bioethical Decisions About Nuclease-Mediated SCGE in General -- Sickle-Cell Disease -- Current Therapeutic Approaches to Sickle-Cell Disease -- Bioethical Decision-Making About Hematopoietic Stem Cell Transplantation-Based Cures for Sickle-Cell Disease -- The Nuclease-Mediated SCGE Approach to Sickle-Cell Disease -- Bioethical Decision-Making About Ex-Vivo Nuclease-Mediated SCGE -- Nonmaleficence -- Beneficence -- Autonomy -- Justice -- Conclusion -- References -- Chapter 6: Gene Therapy and Germline Cells Research -- Introduction -- How Is Germline Gene Therapy Technically Possible? Advancing Germline Genomic Editing Techniques Through CRISPR/Cas9, a Nobel Prize Winning Combination -- Gene Therapy: Definitions, Differentiations and Applications -- When Do We Really Talk About Germline Gene Therapy? One Step Beyond the Dichotomy Between Therapeutic and Non-Therapeutic -- Fear of a Eugenic Drift and the Controversial Violation of Human Dignity: Two Major Bioethical Objections to Germline Gene Therapy -- Does Eradicating Disease Mean Eradicating the Sick? Disabilites Rights Critique and Germline Gene Therapy -- Conclusions |
| Summary |
"The Handbook of Bioethical Decisions is aimed at addressing and analyzing the most important ethical concerns and moral quandaries arisen in biomedical and scientific research. As such, it identifies and problematizes on a comprehensive range of ethical issues researchers must deal with in different critical contexts. Thus, the Handbook, Vol. I, may be helpful for them to make decisions and deliberate in complex practical scenarios. In this fashion, the volume reunites different points of view to give readers room enough to get a better knowledge and take their own position on pressing bioethical issues of the day. Consequently, this workseeks to engender dense ethical epistemology scientists can count on when conducting latest generation biomedical research. By bringing together an impressive array of contributions on the most important elements and categories for "at the bench" bioethical decisions as well as offering chapters by some of the most world renowned and prominent experts in bioethics, the Handbook, Vol. I, is a paradigmatic text in its area and a valuable resource for courses on bioethics, and biomedical research, as well as courses that discuss ethics and the biosciences at different professional levels, biomedical industry, pharmacological companies and the public sphere in general."--Provided by publisher |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Description based on online resource; title from digital title page (ProQuest Ebook Central, viewed on November 14, 2023) |
| Subject |
Bioethics.
|
|
Bioethics -- Decision making
|
|
Bioethics
|
| Form |
Electronic book
|
| Author |
Valdés, Erick, editor.
|
|
Lecaros, Juan Alberto, 1972- editor.
|
| ISBN |
9783031294518 |
|
3031294513 |
|
