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Book Cover
E-book

Title Circulating tumor cells : advances in liquid biopsy technologies / Richard J. Cote, Evi Lianidou, editors
Edition Second edition
Published Cham, Switzerland : Springer, [2023]
©2023

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Description 1 online resource (xxi, 668 pages)
Series Current cancer research
Current cancer research.
Contents Part I Liquid Biopsy Technologies -- CTC-Based Liquid Biopsies and Diagnostic Leukapheresis -- Nuclease-Assisted Elimination of Wild-Type DNA -- Exploiting Exosomes for Cancer Diagnosis and Treatment -- Translational Opportunities of Extracellular Vesicles in Biomedicine -- Capture and Concentration of Circulating Cancer-Associated Extracellular Vesicles -- Circulating Tumor Cells (CTC) and Tumor-Derived Extracellular Vesicles (tdEV) -- Part II Technology Development -- Mathematical Oncology to Integrate Multimodal Clinical and Liquid Biopsy Data for the Prediction of Survival -- Microfluidics, CTC Capture, Analysis and Expansion -- Development and Validation of Molecular Assays for Liquid Biopsy Applications -- State of the Art in the Propagation of Circulating Tumor Cells -- Part III Biology -- Transcriptomic Analysis of CTCs -- Insight into Intratumoral Heterogeneity Through Single CTC Sequencing and CDX Analysis -- Molecular Characterization of Single Circulating Tumor Cells in Breast and Ovarian Cancer -- Circulating Tumour Cell Isolation and Molecular Profiling; Potential Therapeutic Intervention -- Dissecting the Molecular Profiles of Circulating Tumor Cells in Models of Breast and Prostate Cancers -- Part IV Clinical Application of the Liquid Biopsy Creating an Annotated Biospecimen Resource for Liquid Biopsy Applications -- Opportunities for Liquid Biopsies to Meet the Challenges of Precision Medicine -- Part V Prognosis and Therapeutic Monitoring -- CTCs in Early Breast Cancer -- NGS Analysis of Plasma cfDNA and cfmiRNA Signatures in Melanoma Brain Metastasis Patients -- ctDNA and Lung Cancer -- Clinical Perspectives in the Use of Liquid Biopsy in Metastatic Breast Cancer -- Circulating Tumor Cells in Men Treated for Prostate Cancer -- The Role of Liquid Biopsy in Brain Tumors -- Part VI The Next Frontier: Liquid Biopsy and Early Cancer Detection -- Early Cancer Detection: Challenges and Opportunities -- The Galleri Assay -- Index
Summary It is well recognized that blood could be the optimal site for evaluating cancer, allowing easy and repeated access for determining prognosis, establishing molecular targets, evaluating the efficacy of therapy, detecting the earliest signs of recurrence, and even detecting cancer at its earliest and most curable stages. The analysis of cancer through blood samples is now known as the liquid biopsy and has been a rich source of research and clinical application. There has been an explosion of interest and progress in liquid biopsy technologies since the first edition of this book. The second edition will expand its focus to now include not only circulating tumor cells (CTC), but also other emerging aspects of the liquid biopsy, including circulating tumor DNA and methylated DNA (ctDNA, ct meDNA), ctRNA, ct miRNA, circulating tumor proteins (and other) biomarkers and circulating tumor derived exosomes (ctExosomes)
Bibliography Includes bibliographical references
Notes Description based on online resource; title from digital title page (viewed on October 06, 2023)
Subject Cancer cells -- Laboratory manuals
Tumors -- Biopsy -- Laboratory manuals
Cancer cells.
Genre/Form Laboratory manuals.
Laboratory manuals.
Manuels de laboratoire.
Form Electronic book
Author Cote, Richard J., editor.
Lianidou, Evi, editor
ISBN 9783031229039
3031229037