Title Enabling novel treatments for nervous system disorders by improving methods for traversing the blood-brain barrier : proceedings of a workshop / Lisa Bain, Noam I. Keren, and Clare Stroud, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Health and Medicine Division, the National Academies of Sciences, Engineering, Medicine

Published Washington, DC : The National Academies Press, [2018] ©2018

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Description 1 online resource (xii, 59 pages) : color illustrations Contents Introduction and overview --Traversing the blood-brain barrier : challenges and opportunities -- Modalities and technologies for brain delivery -- Regulatory considerations for drugs that traverse the blood-brain barrier -- Accelerating research and clinical translation : consortia and public-private partnerships -- Appendixes Summary "Despite substantial advances in developing treatments for the serious illnesses that affect people worldwide, there remains a tremendous unmet need in the treatment of complex neurologic diseases, including neuropsychiatric and neurodegenerative disorders. Chief among the challenges that have hindered the development of therapeutics for central nervous system (CNS) disorders is the blood-brain barrier (BBB). The Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop to explore the challenges associated with the BBB that have thus far stymied development of CNS drugs, examine new technologies that could address these challenges, and highlight potential opportunities for moving the field forward. This publication summarizes the presentations and discussions from the workshop"--Publisher's description Bibliography Includes bibliographical references (pages 41-44) Notes Online resource; title from PDF title page (National Academies Press, viewed June 4, 2018) Subject Nervous system -- Diseases -- Treatment -- Congresses Blood-brain barrier -- Congresses Blood-brain barrier. Drugs -- Design. Nervous System Diseases -- therapy Central Nervous System Agents Blood-Brain Barrier Drug Design Drug Delivery Systems HEALTH & FITNESS -- Diseases -- General. MEDICAL -- Clinical Medicine. MEDICAL -- Diseases. MEDICAL -- Evidence-Based Medicine. MEDICAL -- Internal Medicine. Drugs -- Design Blood-brain barrier Nervous system -- Diseases -- Treatment Genre/Form proceedings (reports) Conference papers and proceedings Conference papers and proceedings. Actes de congrès. Form Electronic book Author Keren, Noam I., rapporteur Stroud, Clare, rapporteur National Academies of Sciences, Engineering, and Medicine (U.S.). Forum on Neuroscience and Nervous System Disorders, issuing body Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Blood-Brain Barrier (Workshop) (2017 : Washington, D.C.), author ISBN 9780309473088 030947308X 9780309473101 0309473101

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