| Description |
1 online resource (ix, 233 pages) : color illustrations |
| Series |
Recent results in cancer research, 0080-0015 ; v. 192 |
|
Recent results in cancer research ; v. 192.
|
| Contents |
Prevention of Bone Metastases -- Contents -- 1 Preclinical Models that Illuminate the Bone Metastasis Cascade -- Abstract -- 1�The Clinical Problem of Bone Metastasis -- 2�Spontaneous Carcinogenesis in Animal Models -- 3�Chemical Induction in Cancer Animal Models -- 4�Transplantable Animal Models -- 4.1 Orthotopic Transplantation -- 4.2 Intra- and Supra-Osseous Implantation -- 4.3 Humanized Transplantation Model -- 4.4 Dorsal Skinfold Chamber Model -- 4.5 Systemic Inoculation of Cancer Cells as a Bone Metastasis Model |
|
5�Genetically Engineered Mouse Models6�Imaging Modalities -- 6.1 Bioluminescent Imaging -- 6.2 Fluorescent Imaging -- 6.3 Multimodality Imaging -- 6.4 Functional Imaging -- 7�Future Perspectives -- Acknowledgments -- References -- 2 The Role of Bone Microenvironment, Vitamin D and Calcium -- Abstract -- 1�Bone Premetastatic Niche -- 1.1 Starting From the Primary Tumor Site: The Cancer Stem Cells -- 1.1.1 Cancer Stem Cell Characteristics -- 1.1.2 The Acquisition of Self-Renewal and Migration Ability (The Epithelial Mesenchymal Transition) |
|
WNT PathwayPTEN Pathway -- Notch Signaling System -- SHH Pathway -- 1.1.3 Tumor-Associated Macrophages -- 1.1.4 Lysyl Oxidase -- 1.2 The Long Way to the Bone: The Importance of Chemokines -- 1.2.1 CXCR4\SDF-1 Pathway -- 1.2.2 RANK\RANK-L Pathway -- 1.2.3 The Integrin System -- 1.2.4 The BMP Receptor Axis -- 1.2.5 Other Adhesion Molecules -- Osteopontin -- Sinusoidal Endothelial Cell Adhesion Molecules -- Endothelin 1 and ET Receptors -- 1.3 Modification of the Bone Microenvironment: Premetastatic Niche Formation -- 1.4 Osteomimicry -- 1.4.1 PTHRP |
|
1.4.2 RANKL\OPG\TRAIL1.4.3 VEGF -- 1.4.4 C-KIT\SCF -- 1.4.5 IGF -- 1.4.6 RUNX -- 1.4.7 The Role of the Calcium Sensing Receptor in Bone Marrow Homing -- 1.5 Role of Calcium, Vitamin D and PTH in the Premetastatic Niche -- 1.5.1 Vitamin D -- 1.5.2 Antineoplastic Effect of Vitamin D -- 1.5.3 Inhibition of NFkB Activation, Angiogenesis, Invasion and Metastasis -- 1.5.4 Calcium -- 1.5.5 PTH -- PTH and Factors Involved in the Premetastatic Niche -- PTH and the Hematopoietic Stem Cell Niche -- References |
|
3 Bisphosphonates: Prevention of Bone Metastases in Breast CancerAbstract -- 1�Introduction -- 2�Bone-Targeted Therapies for Breast Cancer -- 3�Anticancer Effects of Oral Bisphosphonates in Early Breast Cancer -- 3.1 Oral ClodronateClodronate -- 3.2 Oral PamidronatePamidronate -- 3.3 Anticancer Benefits of Zoledronic Acid -- 3.4 ABCSG-12 -- 3.5 ZO-FAST -- 3.6 AZURE -- 3.7 Is There a Subset of Patients More Likely to Benefit From ZOL Anticancer Effects? -- 3.8 Neoadjuvant Therapy -- 3.9 Further Data From Translational Studies in Early Breast Cancer |
| Summary |
Bone metastases continue to be a major cause of morbidity in cancer patients, but improved understanding of the biology of bone metastases has led to the identification of drugs that are of potential value in not only their treatment but also their prevention. This book, written by recognized experts in the field, provides a detailed overview of current knowledge on this subject. One important focus of the book is the efficacy of bisphosphonates in preventing bone metastases in patients with breast, lung, and prostate cancer and disease progression in cases of multiple myeloma.¡ The combined use of bisphosphonates and cytostatics is also discussed, with a report on first clinical data.¡ Further topics addressed include the significance of the bone microenvironment, special issues in the elderly patient, the use of bone turnover markers, and initial findings obtained with denosumab |
| Analysis |
Medicine |
|
Oncology |
|
Cancer -- Surgery |
|
Medicine & Public Health |
|
Surgical Oncology |
|
geneeskunde |
|
volksgezondheid |
|
public health |
|
oncologie |
|
chirurgie |
|
surgery |
|
Medicine (General) |
|
Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references |
| Subject |
Bone metastasis.
|
|
Biochemical markers.
|
|
Bone Neoplasms -- prevention & control
|
|
Bone Neoplasms -- secondary
|
|
Biomarkers
|
|
Cytostatic Agents -- therapeutic use
|
|
Diphosphonates -- therapeutic use
|
|
HEALTH & FITNESS -- Diseases -- Cancer.
|
|
MEDICAL -- Oncology.
|
|
Médecine.
|
|
Biochemical markers
|
|
Bone metastasis
|
| Form |
Electronic book
|
| Author |
Joerger, Markus.
|
|
Gnant, Michael.
|
| LC no. |
2011944260 |
| ISBN |
9783642218927 |
|
364221892X |
|
