| Description |
1 online resource (xxi, 420 pages) : illustrations (some color) |
| Contents |
Intro -- Preface 1 -- Preface 2 -- Aim of the Book -- Acknowledgments -- I -- II -- Contents -- Chapter 1: Introduction and Historical Background -- 1.1 Leão' Cortical Spreading Depression (CSD) -- 1.1.1 Aristides Leão: Life History -- 1.1.2 The Discovery of the "Spreading Depression" -- 1.1.3 Back to Brazil -- 1.1.4 Conclusion -- 1.1.5 Aristides Leão: The Four Seminal Publications (1944-1947) -- 1.2 Oxygen Homeostasis in the Brain -- 1.2.1 The Discovery of Oxygen -- 1.2.2 The Discovery of the Mitochondrial Function -- 1.3 Monitoring of Brain Mitochondrial Function in Vivo |
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1.4 Brain Energy Metabolism and Mitochondrial Function During CSD -- References -- Chapter 2: Basic Principles and Technology of NADH and Multiparametric Monitoring Used in Studying Cortical Spreading Depression (CSD) -- 2.1 Introduction -- 2.2 From NADH Monitoring to Multiparametric Monitoring Systems -- 2.2.1 Fiber-Optic-Based Fluorometer/Reflectometer -- 2.2.2 Simultaneous Monitoring of NADH by DC Fluorometer Reflectometer Together with Monitoring of Systemic Blood Pressure and Electrocortical Activity (ECoG) |
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2.2.3 Simultaneous Monitoring of NADH Together with Extracellular K+, DC Steady Potential, and ECoG -- 2.2.4 Monitoring of Brain NADH Together with Tissue pO2 and ECoG -- 2.2.5 Multiparametric Assembly for Recording of NADH, Extracellular K+, H+, DC Steady Potential, and ECoG -- 2.2.5.1 Electrode Assembly -- 2.2.5.2 Correction for Local DC Biopotential -- 2.2.5.3 NADH Fluorescence Measurement -- 2.2.6 Monitoring of NADH, pO2, Extracellular K+, DC, and ECoG, Outside and Inside Hyperbaric Chamber |
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2.2.7 Simultaneous Real-Time Monitoring of Brain NADH, HbO2, ECoG, DC Potential, and Extracellular K+ and Ca2+ -- 2.2.8 Simultaneous Real-Time Monitoring of Brain NADH, CBF, ECoG, DC Potential, and Extracellular K+ and Ca2+ -- 2.2.9 Simultaneous Monitoring of Brain NADH, CBF, ECoG, DC Potential, and Extracellular K+, Ca+2, H+ -- 2.2.10 Multiparametric Monitoring of Neurosurgical Patients -- 2.2.11 Monitoring of the Mechanism of CSD Propagation -- 2.2.12 Multisite Monitoring of NADH and DC Potential in Rats Under Various Conditions |
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2.2.13 Multisite Multiparametric Monitoring of NADH, CBF, and DC Potential in Rats Under Experimental Conditions -- References -- Chapter 3: Single Point and Multisite Monitoring of Brain NADH Fluorescence Under CSD -- 3.1 Introduction -- 3.2 Single Point Monitoring of NADH -- 3.3 Two Points Monitoring of NADH -- 3.4 Four Points Monitoring of NADH -- References -- Chapter 4: Sequence of Physiological Responses Recorded During Induced CSD Event -- 4.1 Introduction -- 4.2 Effects of CSD on Cerebral Blood Flow and Brain Oxygen Consumption -- 4.2.1 Introduction -- 4.2.2 Methods -- 4.2.3 Results |
| Summary |
This book focuses on energy metabolism and brain functions related to Cortical Spreading Depression of Leao (CSD), an important issue in brain pathophysiology. The first part of the book offers a comprehensive overview of the history and early research on CSD, and then discusses the recent advances in the technology used to map and monitor brain mitochondrial NADH redox state and other physiological functions during CSD. The chapters explore the connection between CSD and mitochondrial function under hypoxia, Ischemia and various drugs treatment, and provide a resource to scientists researching the development of CSD during various brain pathophysiological conditions. This book is essential to scientists and students working in the field of bioenergetics of the brain and various organs and tissues in the body. The use of this technology is also crucial and applicable in the neuroscience field |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed November 1, 2022) |
| Subject |
Brain -- Pathophysiology
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Brain -- Metabolism -- Disorders
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Mitochondrial pathology.
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Brain -- Pathophysiology
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Mitochondrial pathology
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| Form |
Electronic book
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| Author |
Sonn, Judith, author
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| ISBN |
9783031080685 |
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3031080688 |
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