An autosomal dominant inherited disorder (with a high frequency of spontaneous mutations) that features developmental changes in the nervous system, muscles, bones, and skin, most notably in tissue derived from the embryonic NEURAL CREST. Multiple hyperpigmented skin lesions and subcutaneous tumors are the hallmark of this disease. Peripheral and central nervous system neoplasms occur frequently, especially OPTIC NERVE GLIOMA and NEUROFIBROSARCOMA. NF1 is caused by mutations which inactivate the NF1 gene (GENES, NEUROFIBROMATOSIS 1) on chromosome 17q. The incidence of learning disabilities is also elevated in this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1014-18) There is overlap of clinical features with NOONAN SYNDROME in a syndrome called neurofibromatosis-Noonan syndrome. Both the PTPN11 and NF1 gene products are involved in the SIGNAL TRANSDUCTION pathway of Ras (RAS PROTEINS)
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Cafe (Ballet) : Dance : HSC 2 unit : "Cafe" and "Boxes", contextual notes for the study of two works from Sydney Dance Company
1993
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Cafe Brenda (Minneapolis, Minn.) / http://id.loc.gov/authorities/names/n91112649 : The Cafe Brenda cookbook : seafood and vegetarian cuisine / Brenda Langton and Margaret Stuart
2004
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Cafe Chavalos : Cafe Chavalos : overcoming the streets / directed by Alberto Chamorro ; produced by Alberto Chamorro
2009
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Cafe (Choreographic work) : Dance : HSC 2 unit : "Cafe" and "Boxes", contextual notes for the study of two works from Sydney Dance Company
Cafe Spice (Packaged food supplier) / http://id.loc.gov/authorities/names/n2014045875 : The Cafe Spice cookbook : 84 quick and easy Indian recipes for everyday meals / Hari Nayak ; photography by Jack Turkel
Here are entered works on programs which allow employees to choose fringe benefits within the limits of the total benefit amounts for which they are eligible
A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling
Caffeine -- adverse effects : Caffeine in food and dietary supplements : examining safety : workshop summary / Leslie Pray, Ann L. Yaktine, and Diana Pankevich, rapporteurs ; planning Committee for a workshop on Potential Health Hazards Associated with Consumption of Caffeine in Food and Dietary Supplements, Food and Nutrition Board, Board on Health Sciences Policy, Institute of Medicine of the National Academies
Caffeine habit -- Congresses. : Caffeinated beverages : health benefits, physiological effects, and chemistry / Thomas H. Parliment, Chi-Tang Ho, Peter Schieberle, editors
