Title Novel therapeutic approaches for gastrointestinal malignancies / Ganji Purnachandra Nagaraju, Sujatha Peela, editors

Published Singapore : Springer, 2020

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Description 1 online resource (xii, 259 pages) : illustrations (some color) Series Diagnostics and Therapeutic Advances in GI Malignancies, 2662-2688 Diagnostics and therapeutic advances in GI malignancies, 2662-2688 Contents Intro -- Preface -- Contents -- About the Editors -- Chapter 1: Targeting Pathways in GI Malignancies -- 1.1 Introduction -- 1.2 Important Targeting Pathways in Esophageal Cancer -- 1.2.1 MAPK Signaling Pathway -- 1.2.2 PI3K/Akt Pathway -- 1.3 Important Targeting Pathways in Gastric Cancer -- 1.3.1 EGFR and HER2 Signaling Pathway -- 1.3.2 The VEGF Pathway -- 1.3.3 The PI3K/AKT/MTOR Pathway -- 1.3.4 The HGF/MET Pathway -- 1.3.5 The RhoA Signaling Pathway -- 1.3.6 The JAK/STAT Pathway -- 1.4 Important Targeting Pathways in CRC -- 1.4.1 EGFR/MAPK Signaling Pathway -- 1.4.2 Notch Pathway 2.3.4 Pancreatic Cancer (PC) -- 2.4 Combining Immunotherapy with Precision Medicine -- 2.5 Conclusions -- References -- Chapter 3: Adiponectin in Gastrointestinal Malignancies -- 3.1 Introduction -- 3.2 Adiponectin and Adiponectin Receptors -- 3.3 Connection Between Obesity and Gastrointestinal Malignancies -- 3.4 Adiponectin and Obesity-Related Gastrointestinal Malignancies -- 3.4.1 Adiponectin and Gastric Cancer -- 3.4.2 Adiponectin and Colorectal Cancer -- 3.5 Conclusions and Adiponectin as a Therapeutic Agent -- References Chapter 4: Small Molecule-Targeted Therapies for GI Cancers: Success and Failures -- 4.1 Introduction -- 4.2 Targeted Therapies -- 4.2.1 Immunotherapy -- 4.2.2 Small Molecule-Based Targeted Therapeutics -- 4.2.2.1 Protein Kinase Inhibitors -- 4.2.2.2 Proteasome Inhibitors -- 4.2.2.3 Matrix Metalloproteinase Inhibitors -- 4.3 Limitations of Small Molecule Inhibitor Targeted Therapies -- 4.4 Conclusion -- References -- Chapter 5: Epigenetic Biomarkers for the Detection of Gastrointestinal Cancers -- 5.1 Introduction -- 5.2 Colorectal Carcinoma and Gastric Adenocarcinoma 5.3 Epigenetic Alterations and Its Relevance to Cancer -- 5.4 Major Epigenetic Modifications: Significances and Consequences (Fig. 5.2) -- 5.4.1 Epigenetic Modification Involving Methylation of DNA -- 5.4.1.1 Methylation Status of DNA as a Reliable Marker for Colorectal Cancers (CRC) -- 5.4.1.2 Methylation Status of DNA as a Reliable Marker for Gastric Cancers (GC) -- 5.4.2 Histone Modification as an Epigenetic Alteration -- 5.4.2.1 Histone Acetylation -- 5.4.2.2 Histone Methylation -- 5.4.2.3 Histone Phosphorylation -- 5.4.2.4 Histone Modification Based Biomarkers for Colorectal Cancers Summary This book provides an up-to-date overview of gastrointestinal malignancies, including prevention, early detection, intervention, and life-extending therapeutics. It also assesses various biomarkers used for diagnostics, prognostics and prediction of response to chemoresistance. Further, it discusses the latest trends in the use of small-molecule targeted therapies and immunotherapies as single agents or combination with other treatments. Since resistance to radiation and chemotherapy contribute to the high recurrence and poor survival rates, improving the outcome for GI malignancies is dependent on the introduction of new biomarkers and therapeutic agents. Lastly, the book systematically investigates novel theranostics approaches using nanotechnology for the detection, diagnosis, and personalized treatment of GI malignancies Bibliography Includes bibliographical references Notes Online resource; title from PDF title page (SpringerLink, viewed November 30, 2020) Subject Gastrointestinal system -- Cancer -- Treatment Gastrointestinal system -- Cancer -- Diagnosis Gastrointestinal system -- Cancer -- Prevention Cancer -- Research. Nanotechnology. Radiology. Gene expression. Gastrointestinal Neoplasms -- therapy Gastrointestinal Neoplasms -- diagnosis Biomarkers, Tumor -- therapeutic use Molecular Targeted Therapy -- methods Immunotherapy -- methods Theranostic Nanomedicine -- methods Radiology Gene Expression Nanotechnology radiology. Nanotechnology. Radiology. Medical genetics. Oncology. Technology & Engineering -- Nanotechnology & MEMS. Medical -- Diagnostic Imaging. Medical -- Genetics. Medical -- Oncology. Cancer -- Research Gastrointestinal system -- Cancer -- Diagnosis Gastrointestinal system -- Cancer -- Treatment Gene expression Nanotechnology Radiology Form Electronic book Author Nagaraju, Ganji Purnachandra, editor. Peela, Sujatha, editor ISBN 9789811554711 9811554714

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