| Description |
1 online resource (xiii, 302 pages) : illustrations |
| Series |
Methods in molecular medicine ; 45 |
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Methods in molecular medicine ; 45.
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| Contents |
Hepatocellular carcinoma : The clinical problem / V. Usatoff and N.A. Habib-Medical management of hepatocellular carcinoma / S.M. Riordan and R. Williams-Possible involvement of the ns3 protein of hepatitis c virus in hepatocarcinogenesis : Its interaction with the p53 tumor suppressor / S. Ishido, T. Fujita and H. Hotta-Abrogation of p53-induced apoptosis by the hepatitis b virus x gene / X. Wei Wang-Hepatocellular carcinoma : Role of hepatitis viruses and liver cell dysplasia / C. Vandelli and F. Renzo-The impact of hepatitis b virus (hbv) and hepatitis c virus (hcv) : From research to clinical practice / M.R. Brunetto, F. Oliveri and F. Bonino-Mutation of p53 tumor suppressor gene in hepatocellular carcinoma / A. Tullo and E. Sbisa-Diagnostic markers in hepatocellular carcinoma using immunohistochemical techniques / Y. Ohene-Abuakwa and M. Pignatelli-Assessing matrix metalloproteinase expression and activity in hepatocellular carcinomas / O. Musso, B. Clement and N. Theret-Isolation of novel markers for hepatocellular carcinoma by a subtraction-enhanced display technique / C.G. Wu-Measurement of protein expression of p53, p21(waf1), and rb in patients with surgically treated hepatocellular carcinoma by using catalyzed signal-amplification system / T. Naka, T. Kaneko and N. Kaibara-Gene therapy vectors harboring afp regulatory sequences : Preparation of an adenoviral vector / S. Kaneko and T. Tamaoki-Advantages and disadvantages of multiple different methods of adenoviral vector construction / P. Seth and J. Higginbotham-Electron microscopic assessment of adenovirus-mediated transfer / C.E. Sarraf-P53 plasmid preparation and techniques for analysis of gene transfer and expression / R.R. Mitry [and others]-Antisense igf-i for hepatocellular carcinoma / Y. Liu [and others]-Novel effective tumor vaccines for hepatocellular carcinoma / L. Wei [and others]-Immunoglobulin fusion proteins as a tool for evaluation of t-cell costimulatory molecules / A.I. Chapoval, G. Zhu and L. Chen-Adenovirus-mediated drug-sensitivity gene therapy for hepatocellular carcinoma / F. Kanai [and others]-Clinical protocol for p53 gene therapy for liver tumors / M.D. Kelly, R.R. Mitry and N.A. Habib |
| Summary |
Advances in molecular characterization and novel gene-isolation techniques have vigorously expanded our understanding of hepatocellular carcinoma (HCC), a form of liver cancer that affects one million people annually, and generated many new therapeutic possibilities. In Hepatocellular Carcinoma: Methods and Protocols, Nagy Habib and a team of basic and clinical researchers describe the wide variety of powerful new laboratory-based molecular methods currently being used for investigating and treating this disease. The book focuses on gene therapy approaches, including the use of such vectors as lipids, adenovirus, and baculovirus, and virus detection assessment using electron microscopy. It also provides preclinical and clinical data on the killing of cancer cells using tumor-suppressor genes, antisense compounds to growth factors, immunotherapy (remove gene), and virus-directed enzyme prodrug therapy. A perspective on future treatment of the failing liver is given, along with a clinical protocol for p53 gene therapy. Hepatocellular Carcinoma: Methods and Protocols offers experimental and clinical investigators a rich source of both basic science and clinical information on today's optimal use of gene therapy to treat and manage patients suffering from hepatocellular carcinoma |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
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Print version record |
| Subject |
Liver -- Cancer -- Research -- Methodology
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Carcinoma, Hepatocellular -- etiology
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Carcinoma, Hepatocellular -- genetics
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Carcinoma, Hepatocellular -- therapy
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Genetic Therapy -- methods
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MEDICAL -- Infectious Diseases.
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HEALTH & FITNESS -- Diseases -- Contagious.
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Liver -- Cancer -- Research -- Methodology
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Wetenschappelijke technieken.
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| Genre/Form |
Laboratory manuals.
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Manuels de laboratoire.
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| Form |
Electronic book
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| Author |
Habib, Nagy A.
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| ISBN |
9781592590797 |
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1592590799 |
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1280820691 |
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9781280820694 |
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9786610820696 |
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6610820694 |
|
