Front Matter; Cellular versus Organismal Aging; Telomere-Induced Senescence of Primary Cells; Telomeres, Senescence, Oxidative Stress, and Heterogeneity; Initiation of Genomic Instability, Cellular Senescence, and Organismal Aging by Dysfunctional Telomeres; Telomerase Mutations and Premature Ageing in Humans; Mechanisms of Stem Cell Ageing; Senescence Signatures of Human Hematopoietic Stem Cells; Telomere Shortening Induces Cell Intrinsic Checkpoints and Environmental Alterations Limiting Adult Stem Cell Function; p16INK4a and Stem Cell Ageing: A Telomere-Independent Process?
Summary
Summarizes experimental evidence and clinical data indicating that telomere dysfunction influences human ageing, diseases and cancer. This book describes our knowledge on checkpoints that limit cellular lifespan (senescence) and survival (apoptosis, crisis) in response to telomere dysfunction
