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Title Checkpoint responses in cancer therapy / edited by Wei Dai
Published Totowa, NJ : Humana Press, 2008


Description 1 online resource (xiii, 314 pages) : illustrations
Series Cancer drug discovery and development
Cancer drug discovery and development.
Contents RB-Pathway -- Targeting the p53/MDM2 Pathway for Cancer Therapy -- DNA Topoisomerases as Targets for the Chemotherapeutic Treatment of Cancer -- Targeting ATM/ATR in the DNA Damage Checkpoint -- Compounds that Abrogate the G2 Checkpoint -- CDK Inhibitors as Anticancer Agents -- CHFR as a Potential Anticancer Target -- Antimicrotubule Agents -- Kinesin Motor Inhibitors as Effective Anticancer Drugs -- Targeting the Spindle Checkpoint in Cancer Chemotherapy -- Antiproliferation Inhibitors Targeting Aurora Kinases -- Plks as Novel Targets for Cancer Drug Design -- Do Histone Deacetylase Inhibitors Target Cell Cycle Checkpoints that Monitor Heterochromatin Structure?
Summary Extensive research has uncovered a set of molecular surveillance mechanisms - commonly called "checkpoints"--Which tightly monitor cell-cycle processes. Today's anticancer drug development has identified many of these cell-cycle checkpoint molecules as effective targets. Research now promises to uncover a new generation of anticancer drugs with improved therapeutic indices based on their ability to target emerging checkpoint components. Checkpoint Responses in Cancer Therapy summarizes the advances made over the past 20 years, identifying components of cell-cycle checkpoints and their molecular regulation during checkpoint activation and validating the use of checkpoint proteins as targets for the development of anticancer drugs. This book's distinguished panel of authors takes a close look at topics ranging from the major molecular players affecting DNA synthesis and the response to DNA damage to advances made in the identification of chemical compounds capable of inhibiting individual mitotic kinases. Illuminating and authoritative, Checkpoint Responses in Cancer Therapy offers a critical summary of findings for researchers in the pharmaceutical and biotechnology industries and a valuable resource for academic scientists in cancer research and the study of cell-cycle regulation, signal transduction and apoptosis
Analysis neoplasms
biomedische wetenschappen
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Antineoplastic agents.
Cell cycle -- Regulation.
Oncogenes -- genetics
Cell Transformation, Neoplastic -- drug effects
Cell Proliferation -- drug effects
Gene Expression Regulation, Neoplastic
Antineoplastic Agents -- pharmacology
Neoplasms -- drug therapy
Cell cycle -- Regulation.
Neoplasms -- drug therapy.
Oncogenes -- genetics.
Cell Transformation, Neoplastic -- drug effects.
Cell Proliferation -- drug effects.
Gene Expression Regulation, Neoplastic.
Antineoplastic Agents -- pharmacology.
Antineoplastic agents.
Sciences de la vie.
Antineoplastic agents
Cell cycle -- Regulation
Form Electronic book
Author Dai, Wei (Environmental medicine teacher)
ISBN 9781597452748