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Title Acute neuronal injury : the role of excitotoxic programmed cell death mechanisms / edited by Denson G. Fujikawa
Published New York ; London : Springer, ©2010


Description 1 online resource
Series 2010 Springer E-Books
Contents Caspase-Independent Programmed Cell Death: General Considerations -- Caspase-Independent Cell Death Mechanisms in Simple Animal Models -- Programmed Necrosis: A "New" Cell Death Outcome for Injured Adult Neurons? -- Age-Dependence of Neuronal Apoptosis and of Caspase Activation -- Excitotoxic Programmed Cell Death Involves Caspase-Independent Mechanisms -- Focal Cerebral Ischemia -- Significant Role of Apoptosis-Inducing Factor (AIF) for Brain Damage Following Focal Cerebral Ischemia -- The Role of Poly(ADP-Ribose) Polymerase-1 (PARP-1) Activation in Focal Cerebral Ischemia -- Transient Global Ischemia -- Transient Global Cerebral Ischemia Produces Morphologically Necrotic, Not Apoptotic Neurons -- Apoptosis-Inducing Factor Translocation to Nuclei After Transient Global Ischemia -- Role of µ-Calpain I and Lysosomal Cathepsins in Hippocampal Neuronal Necrosis After Transient Global Ischemia in Primates -- Traumatic Central Nervous System (CNS) Injury -- Mitochondrial Damage in Traumatic CNS Injury -- Programmed Neuronal Cell Death Mechanisms in CNS Injury -- Hypoglycemic Neuronal Death -- Hypoglycemic Brain Damage -- Hypoglycemic Neuronal Death -- Seizure-Induced Neuronal Death -- Tumor Suppressor p53: A Multifunctional Protein Implicated in Seizure-Induced Neuronal Cell Death -- DNA Damage and Repair in the Brain: Implications for Seizure-Induced Neuronal Injury, Endangerment, and Neuroprotection -- Activation of Caspase-Independent Programmed Pathways in Seizure-Induced Neuronal Necrosis
Summary This book is the result of a convergence of scientific information regarding mechanisms that produce acute nerve cell death in the brain. Although seemingly disparate, stroke, brain and spinal cord trauma, coma from a low serum glucose concentration (hypoglycemia), and prolonged epileptic seizures have in common the inciting factor of excitotoxicity, the activation of a specific subtype of glutamate receptor by an elevated extracellular glutamate concentration that results in an excessive influx of calcium into nerve cells. The high calcium concentration in nerve cells activates several enzymes that are responsible for degradation of cytoplasmic proteins and cleavage of nuclear DNA, resulting in nerve cell death. The high calcium concentration also interferes with mitochondrial respiration, with the resultant production of free radicals that damage cellular membranes and nuclear DNA. Understanding the biochemical pathways that produce nerve cell death is the first step toward devising an effective neuroprotective strategy, the ultimate goal. Acute Neuronal Injury will be useful to neuroscientists and general cell biologists interested in cell death. The book will also be helpful to clinically oriented neuroscientists, including neurologists, neurosurgeons and psychiatrists. About the Editor: Dr. Denson Fujikawa is an Adjunct Professor of Neurology at the David Geffen School of Medicine at UCLA, a member of the Brain Research Institute at UCLA and a Staff Neurologist at the Department of Veterans Affairs Greater Los Angeles Healthcare System. His interest in mechanisms of nerve cell death in the brain began during a two-year epilepsy research fellowship with Dr. Claude Wasterlain, from 1981 to 1983. He is a Fellow of the American Academy of Neurology and is a member of the American Epilepsy Society, American Neurological Association, International Society for Cerebral Blood Flow and Metabolism, and the Society for Neuroscience
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Nervous system -- Diseases -- Cytopathology
Cell death.
Nervous system -- Diseases.
Apoptosis -- physiology
Nervous System Diseases -- etiology
Cell Death
Nervous System Diseases -- pathology
Nervous System Diseases -- physiopathology
Neurons -- cytology
Nervous System Diseases
HEALTH & FITNESS -- Diseases -- Nervous System (incl. Brain)
MEDICAL -- Neurology.
Nervous system -- Diseases -- Cytopathology.
Cell death.
Nervous system diseases -- Pathology.
Sciences de la vie.
Cell death
Form Electronic book
Author Fujikawa, Denson G.
ISBN 9780387732268