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Book Cover

Title Cell culture and upstream processing / edited by Michael Butler
Published New York ; Abingdon [England] : Taylor & Francis, ©2007


Description 1 online resource (xiv, 187 pages) : illustrations
Contents Cell line development and culture strategies : future prospects to improve yields / Michael Butler -- Use of DNA insulator elements and scaffold/matrix-attached regions for enhanced recombinant protein expression / Helen Kim -- Targeted gene insertion to enhance protein production from cell lines / Trevor N. Collingwood and Fyodor D. Urnov -- Recombinant IgG production from myeloma and Chinese hamster ovary cells / Ray Field -- Cell culture media development : customization of animal origin-free components and supplements / Stephen Gorfien -- Post-translational modification of recombinant proteins / Roy Jeffries -- Metabolic engineering to control glycosylation / Amy Shen [and others] -- An alternative approach : humanization of N-glycosylation pathways in yeast / Stefan Wildt and Thomas Potgieter -- Perfusion or fed-batch? : a matter of perspective / Marco Cacciuttolo
Summary Upstream processing refers to the production of proteins by cells genetically engineered to contain the human gene which will express the protein of interest. The demand for large quantities of specific proteins is increasing the pressure to boost cell culture productivity, and optimizing bioreactor output has become a primary concern for most pharmaceutical companies. Each chapter in "Cell Culture and Upstream Processing" is taken from presentations at the highly acclaimed IBC conferences as well as meetings of the European Society for Animal Cell Technology (ESACT) and Protein Expression in Animal Cells (PEACe) and describes how to improve yield and optimise the cell culture production process for biopharmaceuticals, by focusing on safety, quality, economics and operability and productivity issues. "Cell Culture and Upstream Processing" will appeal to a wide scientific audience, both scientific practitioners of animal cell technology as well as students of biochemical engineering or biotechnology in graduate or high level undergraduate courses at university
Notes "From presentations at the ... IBC conferences as well as meetings of the European Society for Animal Cell Technology (ESACT) and Protein Expression in Animal Cells (PEACe)."
Bibliography Includes bibliographical references and index
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
Print version record
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Subject Cell culture -- Congresses
Biochemical engineering -- Congresses
Biotechnology -- Congresses
Cell Culture Techniques -- methods
Genetic Engineering -- methods
SCIENCE -- Biotechnology.
Biochemical engineering
Cell culture
Genre/Form Electronic books
proceedings (reports)
Conference papers and proceedings
Conference papers and proceedings.
Actes de congrès.
Form Electronic book
Author Butler, M. (Michael), 1947-
ISBN 9780203967232