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Title Cell death : the role of Poly (ADP-ribose) polymerase / edited by Csaba Szabó
Published Boca Raton : CRC Press, ©2000


Description 1 online resource (338 pages) : illustrations
Series Pharmacology and toxicology
Pharmacology & toxicology (Boca Raton, Fla.)
Contents Cell Death by Energy Depletion: A Reemerging Concept via the Nitric Oxide Connection / Csaba Sabó and Solomon H. Snyder -- Nitric Oxide and Poly(ADP-Ribose) Polymerase in Neuronal Cell Death / Jie Zhang and Solomon H. Snyder -- Role of Poly(ADP-Ribose) Polymerase Mediating Acute and Chronic Neuronal Injury and Neurodegeneration / Valina L. Dawson and Ted M. Dawson -- Importance of Poly(ADP-Ribose) Polymerase Activation in Myocardial Reperfusion Injury / Basilia Zingarelli -- Role of Poly(ADP-Ribose) Polymerase Activation in Inflammation / Andrew L. Salzman -- Poly(ADP-Ribose) Polymerase Activation and the Pathogenesis of Circulatory Shock / Csaba Szabó -- Role of Poly(ADP-Ribose) Polymerase in the Pathogenesis of Pancreatic Islet Cell Death and Type 1 Diabetes / Volker Burkart -- Poly(ADP-Ribose) Polymerase in the Immune System: Focus on Reactive Nitrogen Intermediates and Cell Death / Lásló Virág -- Protective Effect of Poly(ADP-Ribose) Polymerase Inhibitors against Cell Damage Induced by Antiviral and Anticancer Drugs / Balázs Sümegi, György Rablóczky, Ildikó Rácz [and others] -- Involvement of Poly(ADP-Ribose) Polymerase in the Cellular Response to DNA Damage / Claude Niedergang, F. Javier Oliver, Josianne Ménissier-de Murcia [and others] -- Role of Poly(ADP-Ribose) Polymerase in Apoptosis / Marc Germain, A. Ivana Scovassi, and Guy G. Poirer -- Poly(ADP-Ribose) Polymerase is an Active Participant in Programmed Cell Death and Maintenance of Genomic Stability / Dean S. Rosenthal, Cynthia M. Simbulan-Rosenthal, William J. Smith [and others] -- Pleiotropic Roles of Poly(ADP-Ribosyl)ation of DNA-Binding Proteins / Cynthia M. Simbulan-Rosenthal, Dean S. Rosenthal, and Mark E. Smulson -- Poly(ADP-Ribose) Polymerase Inhibition by Genetic and Pharmacological Means / Jie Zhang and Jia-He Li -- Determination of Poly(ADP-Ribose) Polymerase Activation and Cleavage during Cell Death / El Bachir Affar, Stéphane Gobeil, Marc Germain [and others] -- Isoforms of Poly(ADP-Ribose) Polymerase: Potential Roles in Cell Death / Elaine L. Jacobson and Myron K. Jacobson -- Index
Summary Featuring contributions from researchers in a diverse range of fields, this text examines PARP and cell death. It also explores PARP and apoptosis, PARP and DNA repair, and PARP and regulation of gene expression. Separate chapters focus on novel ways of measuring PARP activation
Bibliography Includes bibliographical references and index
Subject Cell death.
DNA damage.
DNA repair.
Cell Death -- physiology
DNA Damage
DNA Repair
Oxidative Stress -- physiology
Poly(ADP-ribose) Polymerases -- physiology
ADP Ribose Transferases
SCIENCE -- Life Sciences -- Anatomy & Physiology.
Cell death
DNA damage
DNA repair
Lésions de l'ADN.
Réparation de l'ADN.
Poly(ADP-ribose) polymerases -- physiologie.
Stress oxydatif -- physiologie.
Form Electronic book
Author Szabó, Csaba, M.D.
ISBN 9781420038897
Other Titles Role of PARP