Frontmatter -- Preface -- Contents -- CHAPTER 1. Introduction -- CHAPTER 2. History of Somatic Hybridization -- CHAPTER 3. Application of Cell Hybridization to the Study of Formal Genetics -- CHAPTER 4. Preliminary Technical and Theoretical Remarks on the Study of Cell Differentiation In Vitro -- CHAPTER 5. Application of Cell Hybridization to the Study of Differentiation: I. Reactivation of Nuclei of Differentiated Cells in Heterokaryons -- CHAPTER 6. Application of Cell Hybridization to the Study of Differentiation: II. The Fate of Luxury Functions in Somatic Hybrids -- CHAPTER 7. Application of Cell Hybridization to the Study of Cancer -- CHAPTER 8. Concluding Remarks and Postscript -- Appendix -- References -- Author Index -- Subject Index
Summary
Since its discovery in I960, the hybridization of somatic cells has evolved from a biological curiosity into an analytical method that today underlies nearly all investigations of the genetic aspects of various biological phenomena. As an eyewitness to this development from its inception forward, Boris Ephrussi here relates the history of somatic hybridization and the formation of its methodology, lie follows with a discussion of the characteristics and properties of the resultant hybrid cells. Together, these topics comprise an authoritative introduction to the principles of the technique
