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Title Drug testing in vitro : breakthroughs and trends in cell culture technology / edited by Uwe Marx and Volker Sandig
Published Weinheim : Wiley-VCH, [2007]
Online access available from:
Wiley Online Books    View Resource Record  


Description 1 online resource (xix, 298 pages) : illustrations
Contents Intelligent biomatrices and engineered tissue constructs : in-vitro models for drug discovery and toxicity testing / Philip Lazarovici, Mengyan Li, Anat Perets, Mark J. Mondrinos, Shimon Lecht, Christopher D. Koharski, Paul R. Bidez III, Christine M. Finck, Peter I. Lelkes -- An overview on bioreactor design, prototyping and process control for reproducible three-dimensional tissue culture / Ralf Pörtner, Christoph Giese -- An overview on bioelectronic and biosensoric microstructures supporting high-content screening in cell cultures / Andrea A. Robitzki, Andrée Rothermel -- Novel in-vitro exposure techniques for toxicity testing and biomonitoring of airborne contaminants / Amanda Hayes, Shahnaz Bakand, Chris Winder -- Drug screening using cell lines : cell supply, high-throughput and high-content assays / Christa Burger, Oliver Pöschke, Mirek R. Jurzak -- Cell lines and primary tissues for in-vitro evaluation of vaccine efficacy / Anthony Meager -- Designer cells derived from primary tissue and designed cell lines as a sustainable cell source for drug discovery and safety assessment / Volker Sandig, Ingo Jordan -- How human embryonic stem cell research can impact in-vitro drug screening technologies of the future / André Schrattenholz, Martina Klemm -- Availability, standardization and safety of human cells and tissues for drug screening and testing / Glyn N. Stacey, Thomas Hartung -- Ethical environment and scientific rationale towards in-vitro alternatives to animal testing: where are we going? / Horst Spielmann -- How drug development of the 21st century could benefit from human micro-organoid in-vitro technologies
Summary Here, expert scientists from industry and academia share their knowledge on the assembly of functional human tissues in vitro and how to design drug screenings predictive of human exposure. In so doing, they combine the latest technological developments with strategic outlooks, such as novel cell and tissue systems for drug screening and testing, as well as emerging in vitro culture technologies. Equally importantly, the book does not shy away from regulatory acceptance and ethical issues
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Cell culture -- Technological innovations.
Drugs -- Testing.
Cell Culture Techniques.
Drug Evaluation, Preclinical.
Form Electronic book
Author Marx, Uwe, editor
Sandig, Volker, editor
Wiley InterScience (Online service)
ISBN 1280854405
3527609563 (electronic bk.)
9783527609567 (electronic bk.)
(alk. paper)
(alk. paper)