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Title Gadd45 stress sensor genes / M. Raza Zaidi, Dan A. Liebermann, editors
Edition Second edition
Published Cham : Springer, 2022


Description 1 online resource (159 pages)
Series Advances in Experimental Medicine and Biology ; v. 1360
Advances in experimental medicine and biology ; v. 1360.
Contents GADD45 in Stress Signaling, Cell Cycle Control, and Apoptosis -- GADD45 in Development and Cancer -- GADD45 in Normal Hematopoiesis and Leukemia -- GADD45 in DNA Methylation and DNA Repair -- GADD45 Proteins in Immunity -- GADD45 in Liver Function and Cancer -- GADD45 in Pre-Eclampsia -- GADD45 in Senescence -- GADD45 in Neuronal Development, Function, and Injury -- Index
Summary This second edition is fully updated throughout and covers the emerging evidence that indicates that the Gadd45 family of proteins plays a unique and critical role as sensors of stress, including genotoxic, physiological, and oncogenic stress. It sheds light on the complex cellular stress response, encompassing myriad molecular pathways with a plethora of regulators and effectors. The GADD45 stress response genes encode small (18 kd) nuclear/cytoplasmic proteins. These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. Despite marked similarities, Gadd45 genes are regulated differentially and exhibit functional diversity. Gadd45 proteins respond to physiological and oncogenic stress, and are implicated in cell cycle arrest, DNA demethylation and repair, apoptosis, cell survival, genomic stability, and inflammation. The purpose of this book is to provide a comprehensive overview of the unique global role that Gadd45 proteins play as stress sensors and the molecular pathways involved
Subject Human molecular genetics.
Protein-protein interactions.
Cellular signal transduction.
Intracellular Signaling Peptides and Proteins -- physiology
Stress, Physiological -- metabolism
Cell Cycle Checkpoints -- physiology
Cell Cycle Checkpoints -- metabolism
Signal Transduction
Cellular signal transduction
Human molecular genetics
Protein-protein interactions
Genètica molecular humana.
Transducció de senyal cel·lular.
Fisiologia cel·lular.
Metabolisme cel·lular.
Genre/Form Llibres electrònics.
Form Electronic book
Author Zaidi, M. Raza
Liebermann, Dan A., 1949-
ISBN 9783030948047