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Title Checkpoint controls and targets in cancer therapy / edited by Zahid H. Siddik
Published Totowa, N.J. ; London : Humana, 2009


Description 1 online resource (xiv, 273 pages) : illustrations (some color)
Series Cancer drug discovery and development
Cancer drug discovery and development.
Contents 1. Circuitry of Checkpoint Response -- Evasion of G1 Checkpoints in Cancer -- Distinct Pathways Involved in S-Phase Checkpoint Control -- Mechanisms of G2 Phase Arrest in DNA Damage-Induced Checkpoint Response -- 2. Checkpoint Response and the Aetiology of Cancer -- Chromatin Modifications and Orchestration of Checkpoint Response in Cancer -- DNA Damage Response and the Balance Between Cell Survival and Cell Death -- Dysfunction of the RB Retinoblastoma Gene in Cancer -- G1 Phase Cyclins in Cancer Development and Progression -- The BRCA1/2 Pathway Prevents Some Leukemias and Lymphomas in Addition to Breast/Ovarian Cancers: Malignancies that Overcome Checkpoint Controls -- 3. Targeting Checkpoint Response in Cancer Therapy -- Regulation of p53 Activity and Associated Checkpoint Controls -- The Importance of p53 Signaling in the Response of Cells to Checkpoint Inhibitors -- Targeting p21-Dependent Pathways for Cell Death in Cancer Therapy -- p27Kip1 as a Biomarker and Target for Treatment of Cancer -- Targeting Cyclin-Dependent Kinases with Small Molecule Inhibitors -- Chk1 and Chk2 as Checkpoint Targets -- Targeting Cdc25 Phosphatases in Cancer Therapy
Summary There is no question that loss of cell cycle checkpoint regulation is an intrinsic characteristic of cancer. However, many tumors retain parallel checkpoint pathways that are activated by antitumor agents and facilitate therapeutic response. Failures in these therapy-linked checkpoint controls are closely associated with cancers that are highly resistant to therapeutic interventions. Checkpoint Controls and Targets in Cancer provides present-day mechanistic understandings of how multiple sets of proteins orchestrate cell cycle progression, discusses critical checkpoint controls that are evaded for cancer development, focuses on checkpoint pathways associated with antitumor effects, and identifies specific checkpoint regulators for targeting with small molecules in the clinical management of cancer. These aspects of cell cycle checkpoints are articulated critically by renowned experts from both academia and industry, and new concepts are forwarded that challenge existing dogmas. Collectively, Checkpoint Controls and Targets in Cancer provides a unique collection of insightful contributions, which are timely and offer significant interest and appeal to basic, translational and clinical scientists
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Antineoplastic agents -- Development.
Cancer cells -- Growth -- Regulation.
Cellular control mechanisms.
Drug resistance in cancer cells.
Neoplasms -- drug therapy
Antineoplastic Agents -- pharmacology
Cell Cycle -- drug effects
Cell Cycle Proteins -- drug effects
Drug Resistance, Neoplasm
SCIENCE -- Life Sciences -- Biology -- Developmental Biology.
Drug resistance in cancer cells
Antineoplastic agents -- Development
Cancer cells -- Growth -- Regulation
Cellular control mechanisms
Form Electronic book
Author Siddik, Zahid H.
ISBN 9781607611783