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Author Radmaneshfar, Elahe, author

Title Mathematical modelling of the cell cycle stress response / Elahe Radmaneshfar
Published Cham : Springer, 2014


Description 1 online resource (xv, 109 pages) : illustrations (some color)
Series Springer theses, 2190-5053
Springer theses, 2190-5053
Contents A biological overview of the cell cycle and its response to osmotic stress and the [alpha]-factor -- ODE model of the cell cycle response to osmotic stress -- Boolean model of the cell cycle response to stress -- Conclusion -- List of equations, parameters and initial conditions -- Effect of methods of update on existence of fixed points
Summary The cell cycle is a sequence of biochemical events that are controlled by complex but robust molecular machinery. This enables cells to achieve accurate self-reproduction under a broad range of conditions. Environmental changes are transmitted by molecular signaling networks, which coordinate their actions with the cell cycle. This work presents the first description of two complementary computational models describing the influence of osmotic stress on the entire cell cycle of S. cerevisiae. Our models condense a vast amount of experimental evidence on the interaction of the cell cycle network components with the osmotic stress pathway. Importantly, it is only by considering the entire cell cycle that we are able to make a series of novel predictions which emerge from the coupling between the molecular components of different cell cycle phases.? The model-based predictions are supported by experiments in S. cerevisiae and, moreover, have recently been observed in other eukaryotes. Furthermore our models reveal the mechanisms that emerge as a result of the interaction between the cell cycle and stress response networks
Notes Ph. D. University of Aberdeen (2013?)
Bibliography Includes bibliographical references
Notes Online resource; title from PDF title page (SpringerLink, viewed October 14, 2013)
Subject Cell cycle -- Mathematical models
SCIENCE -- Life Sciences -- Anatomy & Physiology.
Cell cycle -- Mathematical models
Genre/Form dissertations.
Academic theses
Academic theses.
Thèses et écrits académiques.
Form Electronic book
ISBN 9783319007441