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Title Death receptors in cancer therapy / edited by Wafik S. El-Deiry
Published Totowa, N.J. : Humana Press, ©2005


Description 1 online resource (xi, 374 pages) : illustrations
Series Cancer drug discovery and development
Cancer drug discovery and development.
Contents Mammalian cell death pathways: intrinsic and extrinsic -- Resistance to apoptosis in cancer therapy -- Structures of TNF receptors and their interactions with ligands -- Death receptor signaling in embryonic ectodermal development -- Adaptor proteins in death receptor signalin -- Caspase activation by the extrinsic pathway -- Death signaling and therapeutic applications of TRAIL -- Death receptor mutations -- Regulation of death receptors -- Regulation of trail receptor expression in human melanoma -- Regulation of death receptors by synthetic retinoids -- Role of p53 in regulation of death receptors -- Proapoptotic gene silencing via methylation in human tumors -- Regulation of death receptor-induced apoptosis by NF-kB and interferon signaling pathways: implications for cancer therapy -- TRAIL in cancer therapy -- Expression and regulation of death receptors in multiple myeloma and prostate carcinoma -- Regulation of TRAIL-induced apoptosis by transcriptional factors -- Sensitizing tumor cells by targeting death receptor signaling inhibitors -- Ceramide, ceramidase, and FasL gene therapy in prostate cancer -- Gene therapy targeting receptor-mediated cell death the cancer -- Combination of chemotherapy and death ligands in cancer therapy
Summary This is an in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. The topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Apoptosis.
Cell receptors.
Cancer -- Molecular aspects.
Cellular signal transduction.
Tumor necrosis factor -- Receptors.
Neoplasms -- immunology
Neoplasms -- therapy
Cell Death -- immunology
Genetic Therapy -- methods
Receptors, Tumor Necrosis Factor
Receptors, Cell Surface
Signal Transduction
SCIENCE -- Life Sciences -- Anatomy & Physiology.
Cell receptors.
Cancer -- Molecular aspects.
Cellular signal transduction.
Neoplasms -- immunology.
Neoplasms -- therapy.
Cell Death -- immunology.
Gene Therapy -- methods.
Receptors, Tumor Necrosis Factor.
Tumor necrosis factor -- Receptors
Cancer -- Molecular aspects
Cell receptors
Cellular signal transduction
Form Electronic book
Author El-Deiry, Wafik S
LC no. 2004006682
ISBN 9781592598519